Spots Global Cancer Trial Database for A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma
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Trial Identification
Brief Title: A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma
Official Title: A Phase 3, Randomized, Controlled Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma That Has Progressed After Prior VEGFR Tyrosine Kinase Inhibitor Therapy
Study ID: NCT01865747
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the effect of Cabozantinib (XL184) compared with Everolimus (Afinitor) on progression-free survival (PFS) and overall survival (OS) in subjects with advanced renal cell cancer that has progressed after prior VEGFR tyrosine kinase inhibitor therapy.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
, Birmingham, Alabama, United States
, Anchorage, Alaska, United States
, Gilbert, Arizona, United States
, Scottsdale, Arizona, United States
, Tucson, Arizona, United States
, Duarte, California, United States
, La Jolla, California, United States
, Los Angeles, California, United States
, Los Angeles, California, United States
, Vallejo, California, United States
, Aurora, Colorado, United States
, Denver, Colorado, United States
, New Haven, Connecticut, United States
, Washington, District of Columbia, United States
, Boca Raton, Florida, United States
, Miami, Florida, United States
, Miami, Florida, United States
, Orlando, Florida, United States
, Tampa, Florida, United States
, Chicago, Illinois, United States
, Chicago, Illinois, United States
, Chicago, Illinois, United States
, Iowa City, Iowa, United States
, Westwood, Kansas, United States
, Baltimore, Maryland, United States
, Baltimore, Maryland, United States
, Boston, Massachusetts, United States
, Ann Arbor, Michigan, United States
, Detroit, Michigan, United States
, Detroit, Michigan, United States
, Rochester, Minnesota, United States
, Saint Louis, Missouri, United States
, Las Vegas, Nevada, United States
, Albany, New York, United States
, New York, New York, United States
, Durham, North Carolina, United States
, Cleveland, Ohio, United States
, Cleveland, Ohio, United States
, Columbus, Ohio, United States
, Portland, Oregon, United States
, Portland, Oregon, United States
, Philadelphia, Pennsylvania, United States
, Pittsburgh, Pennsylvania, United States
, Charleston, South Carolina, United States
, Knoxville, Tennessee, United States
, Memphis, Tennessee, United States
, Nashville, Tennessee, United States
, Nashville, Tennessee, United States
, Austin, Texas, United States
, Bedford, Texas, United States
, Dallas, Texas, United States
, Fort Worth, Texas, United States
, Houston, Texas, United States
, Houston, Texas, United States
, San Antonio, Texas, United States
, Salt Lake City, Utah, United States
, Seattle, Washington, United States
, Vancouver, Washington, United States
, Yakima, Washington, United States
, La Plata, Buenos Aires, Argentina
, Mar Del Plata, , Argentina
, Concord, New South Wales, Australia
, Darlinghurst, New South Wales, Australia
, Kogarah, New South Wales, Australia
, Port Macquarie, New South Wales, Australia
, Randwick, New South Wales, Australia
, Wahroonga, New South Wales, Australia
, Westmead, New South Wales, Australia
, Milton, Queensland, Australia
, Wooloongabba, Queensland, Australia
, Adelaide, South Australia, Australia
, Hobart, Tasmania, Australia
, Bentleight East, Victoria, Australia
, Box Hill, Victoria, Australia
, Wodonga, Victoria, Australia
, Linz, Oberösterreich, Austria
, Wien, , Austria
, Wien, , Austria
, Bonheiden, Antwerpen, Belgium
, Brasschaat, Antwerpen, Belgium
, Bruxelles, Brussels, Belgium
, Leuven, Vlaams Brabant, Belgium
, Roeselare, West-Vlaanderen, Belgium
, Antwerpen, , Belgium
, Liege, , Belgium
, Calgary, Alberta, Canada
, Edmonton, Alberta, Canada
, Vancouver, British Columbia, Canada
, Winnepeg, Manitoba, Canada
, Halifax, Nova Scotia, Canada
, Hamilton, Ontario, Canada
, Kingston, Ontario, Canada
, London, Ontario, Canada
, Oshawa, Ontario, Canada
, Ottawa, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Montreal, Quebec, Canada
, Saskatoon, Saskatchewan, Canada
, Santiago, , Chile
, Olomouc, Olomoucký Kraj, Czechia
, Brno, , Czechia
, Prague, , Czechia
, Herlev, Hovedstaden, Denmark
, Aarhus, Midtjylland, Denmark
, Odense, Syddanmark, Denmark
, Turku, Länsi-Suomen Lääni, Finland
, Helsinki, , Finland
, Caen, Calvados, France
, Besancon, Doubs, France
, Bordeaux, Gironde, France
, Toulouse, Haute-Garonne, France
, Rennes, Ille-et-Vilaine, France
, Nantes, Loire-Atlantique, France
, Lyon, Rhône, France
, Le Mans, Sarthe, France
, Villejuif, Val-de-Marne, France
, Marseille, , France
, Paris, , France
, Freiburg, Baden Wuttemberg, Germany
, Tubingen, Baden-Württemberg, Germany
, Ulm, Baden-Württemberg, Germany
, Erlangen, Bayern, Germany
, Aachen, Nordrhein-Westfalen, Germany
, Essen, Nordrhein-Westfalen, Germany
, Mainz, Rheinland-Pfalz, Germany
, Jena, Thuringen, Germany
, Erfurt, Thüringen, Germany
, Berlin, , Germany
, Dresden, , Germany
, Frankfurt am Main, , Germany
, Guetersloh, , Germany
, Hamburg, , Germany
, Hannover, , Germany
, Heidelberg, , Germany
, Munchen, , Germany
, Munich, , Germany
, Budapest, , Hungary
, Szolnok, , Hungary
, Dublin, , Ireland
, Dublin, , Ireland
, Meldola, Emilia-Romagna, Italy
, Modena, Emilia-Romagna, Italy
, Ravenna, Emilia-Romagna, Italy
, Rome, Lazio, Italy
, Rome, Lazio, Italy
, Genova, Liguria, Italy
, Cremona, Lombardia, Italy
, Bari, Puglia, Italy
, Arezzo, Toscana, Italy
, Terni, Umbria, Italy
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Maastricht, Limburg, Netherlands
, Amsterdam, Noord-Holland, Netherlands
, Leiden, Zuid-Holland, Netherlands
, Rotterdam, Zuid-Holland, Netherlands
, Bialystok, Podlaskie, Poland
, Gdansk, Pomorskie, Poland
, Poznan, Wielkopolskie, Poland
, Warsaw, , Poland
, Lisbon, , Portugal
, Lisbon, , Portugal
, Porto, , Portugal
, Moscow, , Russian Federation
, Omsk, , Russian Federation
, St. Petersburg, , Russian Federation
, Yaroslavl, , Russian Federation
, Presov, , Slovakia
, Zilina, , Slovakia
, Oviedo, Asturias, Spain
, Barcelona, Cataluna, Spain
, Badalona, Cataluña, Spain
, L'Hospitalet de Llobregat, Cataluña, Spain
, Pamplona, Navarra, Spain
, Barcelona, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Málaga, , Spain
, Santiago de Compostela, , Spain
, Seville, , Spain
, Valencia, , Spain
, Lund, Skane Lan, Sweden
, Stockholm, Sodermanlands Lan, Sweden
, Umea, , Sweden
, Taichung, , Taiwan
, Taipei, , Taiwan
, Ankara, , Turkey
, Gaziantep, , Turkey
, Istanbul, , Turkey
, Izmir, , Turkey
, Birmingham, England, United Kingdom
, Derby, England, United Kingdom
, Guildford, England, United Kingdom
, London, England, United Kingdom
, London, England, United Kingdom
, London, England, United Kingdom
, Manchester, England, United Kingdom
, Northwood, England, United Kingdom
, Wirral, England, United Kingdom
, Aberdeen, Scotland, United Kingdom
, Edinburgh, Scotland, United Kingdom
, Glasgow, Scotland, United Kingdom
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