Spots Global Cancer Trial Database for Study of XL092 in Combination With Immuno-Oncology Agents in Subjects With Solid Tumors
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Trial Identification
Brief Title: Study of XL092 in Combination With Immuno-Oncology Agents in Subjects With Solid Tumors
Official Title: A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination With Immuno-Oncology Agents in Subjects With Unresectable Advanced or Metastatic Solid Tumors
Study ID: NCT05176483
Study Description
Brief Summary: This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, PK, preliminary antitumor activity, and effect of biomarkers of XL092 administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) in subjects with advanced solid tumors. In the Expansion Stage, the safety and efficacy of XL092 as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Exelixis Clinical Site #67, Phoenix, Arizona, United States
Exelixis Clinical Site #1, Tucson, Arizona, United States
Exelixis Clinical Site #123, Palo Alto, California, United States
Exelixis Clinical Site #59, Santa Barbara, California, United States
Exelixis Clinical Site #87, Littleton, Colorado, United States
Exelixis Clinical Site #62, New Haven, Connecticut, United States
Exelixis Clinical Site #49, Newark, Delaware, United States
Exelixis Clinical Site #48, Celebration, Florida, United States
Exelixis Clinical Site #11, Gainesville, Florida, United States
Exelixis Clinical Site #78, Jacksonville, Florida, United States
Exelixis Clinical Site #47, Miami, Florida, United States
Exelixis Clinical Site #61, Plantation, Florida, United States
Exelixis Clinical Site #8, Tampa, Florida, United States
Exelixis Clinical Site #26, Chicago, Illinois, United States
Exelixis Clinical Site #4, Indianapolis, Indiana, United States
Exelixis Clinical Site #122, Louisville, Kentucky, United States
Exelixis Clinical Site #14, Baltimore, Maryland, United States
Exelixis Clinical Site #7, Boston, Massachusetts, United States
Exelixis Clinical Site #65, Detroit, Michigan, United States
Exelixis Clinical Site #13, Detroit, Michigan, United States
Exelixis Clinical Site #68, Rochester, Minnesota, United States
Exelixis Clinical Site #2, Omaha, Nebraska, United States
Exelixis Clinical Site #5, Omaha, Nebraska, United States
Exelixis Clinical Site #55, Las Vegas, Nevada, United States
Exelixis Clinical Site #88, East Brunswick, New Jersey, United States
Exelixis Clinical Site #105, Hackensack, New Jersey, United States
Exelixis Clinical Site #60, New York, New York, United States
Exelixis Clinical Site #6, New York, New York, United States
Exelixis Clinical Site #76, Syracuse, New York, United States
Exelixis Clinical Site #12, Durham, North Carolina, United States
Exelixis Clinical Site #10, Cleveland, Ohio, United States
Exelixis Clinical Site #51, Portland, Oregon, United States
Exelixis Clinical Site #104, Hershey, Pennsylvania, United States
Exelixis Clinical Site #98, Philadelphia, Pennsylvania, United States
Exelixis Clinical Site #32, Pittsburgh, Pennsylvania, United States
Exelixis Clinical Site #24, Pittsburgh, Pennsylvania, United States
Exelixis Clinical Site #9, Myrtle Beach, South Carolina, United States
Exelixis Clinical Site #3, Nashville, Tennessee, United States
Exelixis Clinical Site #46, Austin, Texas, United States
Exelixis Clinical Site #111, Dallas, Texas, United States
Exelixis Clinical Site #89, Dallas, Texas, United States
Exelixis Clinical Site #73, Irving, Texas, United States
Exelixis Clinical Site #50, Plano, Texas, United States
Exelixis Clinical Site #70, Tyler, Texas, United States
Exelixis Clinical Site #66, Charlottesville, Virginia, United States
Exelixis Clinical Site #33, Milwaukee, Wisconsin, United States
Exelixis Clinical Site #116, Albury, , Australia
Exelixis Clinical Site #35, Birtinya, , Australia
Exelixis Clinical Site #16, Brisbane, , Australia
Exelixis Clinical Site #42, Saint Leonards, , Australia
Exelixis Clinical Site #36, Sydney, , Australia
Exelixis Clinical Site #94, Graz, , Austria
Exelixis Clinical Site #31, Salzburg, , Austria
Exelixis Clinical Site #106, Wein, , Austria
Exelixis Clinical Site #29, Wien, , Austria
Exelixis Clinical Site #39, Anderlecht, , Belgium
Exelixis Clinical Site #37, Kortrijk, , Belgium
Exelixis Clinical Site #85, Besançon, , France
Exelixis Clinical Site #96, Bordeaux, , France
Exelixis Clinical Site #79, Caen, , France
Exelixis Clinical Site #118, Clermont-Ferrand, , France
Exelixis Clinical Site #109, Lyon, , France
Exelixis Clinical Site #92, Marseille, , France
Exelixis Clinical Site #64, Nice, , France
Exelixis Clinical Site #83, Paris, , France
Exelixis Clinical Site #91, Paris, , France
Exelixis Clinical Site #80, Rennes, , France
Exelixis Clinical Site #63, Saint-Herblain, , France
Exelixis Clinical Site #75, Strasbourg, , France
Exelixis Clinical Site #84, Vandœuvre-lès-Nancy, , France
Exelixis Clinical Site #115, Villejuif, , France
Exelixis Clinical Site #103, Essen, , Germany
Exelixis Clinical Site #113, Hamburg, , Germany
Exelixis Clinical Site #108, Heidelberg, , Germany
Exelixis Clinical Site #82, Herne, , Germany
Exelixis Clinical Site #93, Jena, , Germany
Exelixis Clinical Site #112, München, , Germany
Exelixis Clinical Site #102, Nürtingen, , Germany
Exelixis Clinical Site #107, Trier, , Germany
Exelixis Clinical Site #95, Tübingen, , Germany
Exelixis Clinical Site #86, Be'er Sheva, , Israel
Exelixis Clinical Site #72, Haifa, , Israel
Exelixis Clinical Site #52, Jerusalem, , Israel
Exelixis Clinical Site #71, Petah Tikva, , Israel
Exelixis Clinical Site #69, Tel Aviv, , Israel
Exelixis Clinical Site #38, Zerifin, , Israel
Exelixis Clinical Site #121, Ancona, , Italy
Exelixis Clinical Site #117, Bologna, , Italy
Exelixis Clinical Site #90, Firenze, , Italy
Exelixis Clinical Site #101, Milano, , Italy
Exelixis Clinical Site #81, Milano, , Italy
Exelixis Clinical Site #40, Napoli, , Italy
Exelixis Clinical Site #74, Ravenna, , Italy
Exelixis Clinical Site #30, Grafton, , New Zealand
Exelixis Clinical Site #45, Hamilton, , New Zealand
Exelixis Clinical Site #20, Bydgoszcz, , Poland
Exelixis Clinical Site #28, Gdańsk, , Poland
Exelixis Clinical Site #34, Otwock, , Poland
Exelixis Clinical Site #54, Poznań, , Poland
Exelixis Clinical Site #114, Wrocław, , Poland
Exelixis Clinical Site #41, Badajoz, , Spain
Exelixis Clinical Site #53, Barcelona, , Spain
Exelixis Clinical Site #15, Barcelona, , Spain
Exelixis Clinical Site #27, Barcelona, , Spain
Exelixis Clinical Site #120, L'Hospitalet De Llobregat, , Spain
Exelixis Clinical Site #57, Madrid, , Spain
Exelixis Clinical Site #43, Madrid, , Spain
Exelixis Clinical Site #58, Madrid, , Spain
Exelixis Clinical Site #77, Madrid, , Spain
Exelixis Clinical Site #19, Madrid, , Spain
Exelixis Clinical Site #100, Madrid, , Spain
Exelixis Clinical Site #18, Pamplona, , Spain
Exelixis Clinical Site #119, Santander, , Spain
Exelixis Clinical Site #23, Seville, , Spain
Exelixis Clinical Site #56, Valencia, , Spain
Exelixis Clinical Site #25, Valencia, , Spain
Exelixis Clinical Site #21, Chur, , Switzerland
Exelixis Clinical Site #22, St. Gallen, , Switzerland
Exelixis Clinical Site #44, Winterthur, , Switzerland
Exelixis Clinical Site #110, Cambridge, , United Kingdom
Exelixis Clinical Site #99, London, , United Kingdom
Exelixis Clinical Site #97, Middlesex, , United Kingdom
Contact Details
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