The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Dampening the Reproductive Axis With Continuous Kisspeptin
Official Title: Dampening the Reproductive Axis With Continuous Kisspeptin
Study ID: NCT05971849
Brief Summary: The goal of this study is to assess response to kisspeptin as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals with polycystic ovarian syndrome (PCOS).
Detailed Description: Assignment: All study subjects will undergo the same interventions. Baseline LH secretion patterns of individuals with PCOS will be compared to their LH secretion patterns while receiving a kisspeptin infusion. Delivery of Interventions: * Prior to the inpatient study visit, the subjects will undergo a review of their medical history, physical exam, and screening laboratories. * On the day of the study, the subjects will have an intravenous (IV) line placed and * Undergo up to q10 min blood sampling x 36 hours * Receive an infusion of kisspeptin x 24 hours * Receive up to two kisspeptin IV boluses * Receive up to one gonadotropin-releasing hormone (GnRH) IV bolus
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: No
Massachusetts General Hospital, Boston, Massachusetts, United States
Name: Stephanie B Seminara, MD
Affiliation: Massachusetts General Hospital
Role: PRINCIPAL_INVESTIGATOR