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Spots Global Cancer Trial Database for Dampening the Reproductive Axis With Continuous Kisspeptin

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Dampening the Reproductive Axis With Continuous Kisspeptin

Official Title: Dampening the Reproductive Axis With Continuous Kisspeptin

Study ID: NCT05971849

Study Description

Brief Summary: The goal of this study is to assess response to kisspeptin as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals with polycystic ovarian syndrome (PCOS).

Detailed Description: Assignment: All study subjects will undergo the same interventions. Baseline LH secretion patterns of individuals with PCOS will be compared to their LH secretion patterns while receiving a kisspeptin infusion. Delivery of Interventions: * Prior to the inpatient study visit, the subjects will undergo a review of their medical history, physical exam, and screening laboratories. * On the day of the study, the subjects will have an intravenous (IV) line placed and * Undergo up to q10 min blood sampling x 36 hours * Receive an infusion of kisspeptin x 24 hours * Receive up to two kisspeptin IV boluses * Receive up to one gonadotropin-releasing hormone (GnRH) IV bolus

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Massachusetts General Hospital, Boston, Massachusetts, United States

Contact Details

Name: Stephanie B Seminara, MD

Affiliation: Massachusetts General Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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