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Brief Title: Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma
Official Title: Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma
Study ID: NCT01293539
Brief Summary: The purpose of this study is to show that chemotherapy delivered directly through the artery supplying the eye (ophthalmic artery) to patients with retinoblastoma is a safe and effective treatment alternative to conventional systemic chemotherapy, external beam radiation, and surgical removal of the eye.
Detailed Description: Delivering the chemotherapeutic agent in the arterial system through the ophthalmic artery transforms the treatment of retinoblastoma from systemic chemotherapy to local chemotherapy. Administration of the drug directly to the targeted site thus avoids the complications and adverse events associated with toxicity from systemic, rather than local, chemotherapy.
Minimum Age:
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
The Johns Hopkins Hospital, Baltimore, Maryland, United States
Name: Monica Pearl, M.D.
Affiliation: Johns Hopkins University
Role: PRINCIPAL_INVESTIGATOR