Spots Global Cancer Trial Database for Evolutionary Therapy for Rhabdomyosarcoma
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Trial Identification
Brief Title: Evolutionary Therapy for Rhabdomyosarcoma
Official Title: Evolutionary Inspired Therapy for Newly Diagnosed, Metastatic, Fusion Positive Rhabdomyosarcoma
Study ID: NCT04388839
Conditions
Study Description
Brief Summary: This clinical trial will evaluate 4 different strategies of chemotherapy schedules in newly diagnosed participants with metastatic Fusion Positive (alveolar) Rhabdomyosarcoma. The participant and their physician will choose from: Arm A) a first strike therapy, Arm B) a first strike-second strike (maintenance) therapy, Arm C) an adaptively timed therapy, and Arm D) conventional chemotherapy.
Detailed Description:
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, United States
Children's Hospital of Colorado, Aurora, Colorado, United States
Connecticut Children's Medical Center, Hartford, Connecticut, United States
University of Florida, Gainesville, Florida, United States
University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida, United States
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States
Moffitt Cancer Center, Tampa, Florida, United States
Montefiore Medical Cancer Center, Bronx, New York, United States
Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States
University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States
Carolinas Medical Center, Levine Cancer Institute, Charlotte, North Carolina, United States
Duke Children's Hospital, Durham, North Carolina, United States
Cleveland Clinic, Cleveland, Ohio, United States
Nationwide Children's Hospital, Columbus, Ohio, United States
Vanderbilt - Ingram Cancer Center, Nashville, Tennessee, United States
University of Texas Southwestern Medical Center, Dallas, Texas, United States
MD Anderson, Houston, Texas, United States
Primary Children's Medical Center/Utah, Salt Lake City, Utah, United States
Contact Details
Name: Jonathan Metts, MD
Affiliation: Moffitt Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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