Spots Global Cancer Trial Database for Glucocorticoid-induced Tumour Necrosis Factor Receptor Related Protein (GITR) in Rheumatoid Arthritis

Study Description

Brief Summary: This study aimed to measure serum and synovial fluid (SF) levels of GITR in patients with recent onset RA before and after initiation of therapy

Detailed Description: 1. Technical design: Study design: a longitudinal observational cohort study. This study will be carried out on two groups: * Group (I): fifty early onset rheumatoid arthritis (RA) patients fulfilled the 2010 American college of rheumatology (ACR) - European league against rheumatism (EULAR) classification criteria for RA \[11\]. * Group (II): Twenty healthy individuals of matching age and sex as control group. Both groups will be recruited from the in-patients and out-patients' clinic of the Rheumatology, Rehabilitation\& Physical Medicine Department, Benha University Hospital. All patients will be evaluated at baseline at 6 months follow up using: (A) Clinical evaluation 1. Complete history taking. 2. Thorough clinical examination. 3. Disease activity using DAS28 \[12\] (B) Laboratory assessment: All patients will be subjected to the following measurements: 1. Erythrocyte sedimentation rate (ESR). 2. C reactive protein (CRP). 3. Rheumatoid factor (RF) 4. Anti-cyclic citrullinated peptide (Anti- CCP). 5. glucocorticoid-induced tumour necrosis factor receptor related protein (GITR) (D) Musculoskeletal ultrasound assessment: Ultrasound examinations will be performed for patients and control groups using a Logiq e equipped with a broadband 8- to 13-MHz linear transducer 2. Statistical analysis The collected data will be tabulated and analyzed using suitable statistical computer version.

Keywords

Eligibility

Minimum Age: 16 Years

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Contact Details

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