Spots Global Cancer Trial Database for Flavopiridol in Treating Patients With Recurrent, Locally Advanced, or Metastatic Soft Tissue Sarcoma
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Trial Identification
Brief Title: Flavopiridol in Treating Patients With Recurrent, Locally Advanced, or Metastatic Soft Tissue Sarcoma
Official Title: A Phase II Study of Flavopiridol (HMR 1275; NSC 649890) in Patients With Previously Untreated Metastatic or Locally Advanced Soft Tissue Sarcoma
Study ID: NCT00005974
Conditions
Interventions
Study Description
Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of flavopiridol in treating patients who have recurrent, locally advanced, or metastatic soft tissue sarcoma.
Detailed Description: OBJECTIVES: I. Determine the efficacy of flavopiridol in terms of response rate in patients with previously untreated metastatic or locally advanced soft tissue sarcoma. II. Determine the toxicity of this regimen in these patients. III. Determine the time to progression, early progression rate, and response duration in patients treated with this regimen. OUTLINE: This is a multicenter study. Patients receive flavopiridol IV over 1 hour daily on days 1-3. Treatment continues every 3 weeks in the absence of disease progression or unacceptable toxicity. Patients are followed at 4 weeks and then every 3 months until disease progression or death. PROJECTED ACCRUAL: A total of 15-30 patients will be accrued for this study over 12-18 months.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
St. Mary's/Duluth Clinic Health System, Duluth, Minnesota, United States
Tom Baker Cancer Center - Calgary, Calgary, Alberta, Canada
Lethbridge Cancer Clinic, Lethbridge, Alberta, Canada
Burnaby Hospital Regional Cancer Centre, Burnaby, British Columbia, Canada
Nanaimo Cancer Clinic, Nanaimo, British Columbia, Canada
Penticton Regional Hospital, Penticton, British Columbia, Canada
British Columbia Cancer Agency - Fraser Valley Cancer Centre, Surrey, British Columbia, Canada
Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
BC Cancer Agency, Vancouver, British Columbia, Canada
St. Paul's Hospital - Vancouver, Vancouver, British Columbia, Canada
Capital Health Region (Endeavor Clinical Research), Victoria, British Columbia, Canada
Moncton Hospital, Moncton, New Brunswick, Canada
Doctor Leon Richard Oncology Centre, Moncton, New Brunswick, Canada
Saint John Regional Hospital, Saint John, New Brunswick, Canada
Dr. H. Bliss Murphy Cancer Centre, St. Johns, Newfoundland and Labrador, Canada
Nova Scotia Cancer Centre, Halifax, Nova Scotia, Canada
Royal Victoria Hospital, Barrie, Barrie, Ontario, Canada
William Osler Health Centre, Brampton, Ontario, Canada
Hamilton and Disrict Urology Association, Hamilton, Ontario, Canada
London Health Sciences Centre, London, Ontario, Canada
Cancer Care Ontario-London Regional Cancer Centre, London, Ontario, Canada
Markham Stouffville Hospital, Markham, Ontario, Canada
Trillium Health Centre, Mississauga, Ontario, Canada
Credit Valley Hospital, Mississauga, Ontario, Canada
York County Hospital, Newmarket, Ontario, Canada
North York General Hospital, Ontario, North York, Ontario, Canada
Male Health Centre/CMX Research Inc., Oakville, Ontario, Canada
Lakeridge Health Oshawa, Oshawa, Ontario, Canada
Ottawa Regional Cancer Centre - General Campus, Ottawa, Ontario, Canada
Peterborough Oncology Clinic, Peterborough, Ontario, Canada
Scarborough Hospital - General Site, Scarborough, Ontario, Canada
Hotel Dieu Hospital - St. Catharines, St. Catharines, Ontario, Canada
Northeastern Ontario Regional Cancer Centre, Sudbury, Sudbury, Ontario, Canada
Northwestern Ontario Regional Cancer Centre, Thunder Bay, Thunder Bay, Ontario, Canada
Toronto East General Hospital, Toronto, Ontario, Canada
Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
St. Michael's Hospital - Toronto, Toronto, Ontario, Canada
Mount Sinai Hospital - Toronto, Toronto, Ontario, Canada
Toronto General Hospital, Toronto, Ontario, Canada
Princess Margaret Hospital, Toronto, Ontario, Canada
Women's College Campus, Sunnybrook and Women's College Health Science Center, Toronto, Ontario, Canada
Saint Joseph's Health Centre - Toronto, Toronto, Ontario, Canada
Humber River Regional Hospital, Weston, Ontario, Canada
Cancer Care Ontario - Windsor Regional Cancer Centre, Windsor, Ontario, Canada
Queen Elizabeth Hospital, PEI, Charlottetown, Prince Edward Island, Canada
Centre Universitaire de Sante de l'Estrie - Site Fleurimont, Fleurimont, Quebec, Canada
Hopital Charles Lemoyne, Greenfield Park, Quebec, Canada
Centre Hospitalier Regional de Lanaudiere, Joliette, Quebec, Canada
Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
McGill University Department of Oncology, Montreal, Quebec, Canada
Centre Hospitalier de l'Universite' de Montreal, Montreal, Quebec, Canada
Hopital Sainte Justine, Montreal, Quebec, Canada
Hopital Du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
Kells Medical Research Group Inc., Pointe Claire, Quebec, Canada
Centre Hospitalier Universitaire de Quebec, Pavillion de Quebec, Quebec City, Quebec, Canada
Hopital du Saint-Sacrament, Quebec, Quebec City, Quebec, Canada
Centre Hospitalier Regional de Rimouski, Rimouski, Quebec, Canada
L'Hopital Laval, Ste-Foy, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada
Lions Gate Hospital, North Vancouver, , Canada
Contact Details
Name: Donald G. Morris, MD, PhD, FRCPC
Affiliation: Tom Baker Cancer Centre - Calgary
Role: STUDY_CHAIR
Take Control of Your Skin and Body Changes Today.
Try out Spots for free, set up only takes 2 mins.
Join others from around the world:
