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Spots Global Cancer Trial Database for Gemcitabine in Treating Patients With Recurrent or Refractory Cancer of the Uterus

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Gemcitabine in Treating Patients With Recurrent or Refractory Cancer of the Uterus

Official Title: Evaluation of Gemcitabine in the Treatment of Recurrent or Persistent Leiomyosarcoma of the Uterus

Study ID: NCT00003316

Conditions

Sarcoma

Study Description

Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of gemcitabine in treating patients with recurrent or refractory cancer of the uterus.

Detailed Description: OBJECTIVES: I. Determine the antitumor activity of gemcitabine in patients with recurrent or persistent leiomyosarcoma of the uterus who failed higher priority treatment protocols. II. Determine the toxicity of gemcitabine in these patients. OUTLINE: Patients receive gemcitabine IV over 30 minutes weekly for 3 weeks. Courses repeat every 4 weeks in the absence of unacceptable toxicity and disease progression. Patients with partial response, complete response, or stable disease receive at least 3 courses of therapy. Patients are followed every 3 months for 2 years, then every 6 months for 3 years. PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study within 4 years.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Alabama Comprehensive Cancer Center, Birmingham, Alabama, United States

CCOP - Greater Phoenix, Phoenix, Arizona, United States

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

Chao Family Comprehensive Cancer Center, Orange, California, United States

Walter Reed Army Medical Center, Washington, District of Columbia, United States

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States

Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, United States

University of Chicago Cancer Research Center, Chicago, Illinois, United States

Indiana University Cancer Center, Indianapolis, Indiana, United States

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Radiation Oncology Branch, Bethesda, Maryland, United States

Tufts University School of Medicine, Boston, Massachusetts, United States

University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, United States

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States

University of Minnesota Cancer Center, Minneapolis, Minnesota, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

CCOP - Kansas City, Kansas City, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

CCOP - Southern Nevada Cancer Research Foundation, Las Vegas, Nevada, United States

Cooper Hospital/University Medical Center, Camden, New Jersey, United States

Cancer Center of Albany Medical Center, Albany, New York, United States

State University of New York Health Science Center at Brooklyn, Brooklyn, New York, United States

Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, North Carolina, United States

Duke Comprehensive Cancer Center, Durham, North Carolina, United States

Comprehensive Cancer Center of Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, United States

Barrett Cancer Center, The University Hospital, Cincinnati, Ohio, United States

Ireland Cancer Center, Cleveland, Ohio, United States

Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States

Arthur G. James Cancer Hospital - Ohio State University, Columbus, Ohio, United States

University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States

Abington Memorial Hospital, Abington, Pennsylvania, United States

Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States

Kimmel Cancer Center of Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

CCOP - Upstate Carolina, Spartanburg, South Carolina, United States

Simmons Cancer Center - Dallas, Dallas, Texas, United States

University of Washington Medical Center, Seattle, Washington, United States

Tacoma General Hospital, Tacoma, Washington, United States

NCIC-Clinical Trials Group, Kingston, Ontario, Canada

Contact Details

Name: Katherine Y. Look, MD

Affiliation: Indiana University Melvin and Bren Simon Cancer Center

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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