Spots Global Cancer Trial Database for A Study of R1507 in Participants With Recurrent or Refractory Sarcoma
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Trial Identification
Brief Title: A Study of R1507 in Participants With Recurrent or Refractory Sarcoma
Official Title: A Phase II Trial of R1507, a Recombinant Human Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor for the Treatment of Participants With Recurrent or Refractory Ewing's Sarcoma, Osteosarcoma, Synovial Sarcoma, Rhabdomyosarcoma and Other Sarcomas.
Study ID: NCT00642941
Conditions
Interventions
Study Description
Brief Summary: The study was primarily designed to determine objective response, progression-free survival (PFS), and the safety and tolerability of R1507 in participants with recurrent or refractory Ewing's sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma and other sarcomas including alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma, and myxoid liposarcoma.
Detailed Description:
Keywords
Eligibility
Minimum Age: 2 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope National Medical Center, Duarte, California, United States
UCLA School Of Medicine Mattel's Children's Hospital At UCLA; Division Of Hematology-Oncology, Los Angeles, California, United States
Sarcoma Oncology Center, Santa Monica, California, United States
Stanford Comprehensive Cancer Center, Stanford, California, United States
Washington Cancer Institute; Washington Hospital Center, Washington, District of Columbia, United States
Kootenai Medical Center, Coeur d'Alene, Idaho, United States
Johns Hopkins Hospital, Baltimore, Maryland, United States
NIH/NCI, Bethesda, Maryland, United States
Massachusetts General Hospital; Dana Farber Partnes Cancer Center, Boston, Massachusetts, United States
Dana Farber Partners Can Ctr, Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
Nebraska Methodist Hospital; Onc Hem West, Omaha, Nebraska, United States
Albert Einstein College of Medical Pediatrics; Department of Pediatrics, Bronx, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Carolinas Hematology Oncology Associates; Investigational Drug Services - Pharmacy, Charlotte, North Carolina, United States
Oregon Health and Science University Cancer Institute, Portland, Oregon, United States
Pennsylvania Oncology Hema Asc, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Texas Children's Cancer Center; Baylor College of Medicine, Houston, Texas, United States
University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
Huntsman Cancer Institute; Orthopedic Center, Salt Lake City, Utah, United States
Peter Maccallum Cancer Institute; Medical Oncology, Melbourne, Victoria, Australia
BCCA-Vancouver Cancer Centre, Vancouver, British Columbia, Canada
Institut Bergonie; Oncologie, Bordeaux, , France
Centre Oscar Lambret; Chir Cancerologie General, Lille, , France
Centre Leon Berard; Departement Oncologie Medicale, Lyon, , France
Institut Curie; Oncologie Medicale, Paris, , France
Institut Gustave Roussy; Service Pediatrique, Villejuif, , France
HELIOS Klinikum Bad Saarow; Klinik für Innere Medizin III, Bad Saarow, , Germany
Uniklinik Mannheim; Sektion Chirurgische Onkologie & Thoraxchirurgie, Mannheim, , Germany
University Hospital Tübingen, Tübingen, , Germany
Istituti Ortopedici Rizzoli, Bologna, Emilia-Romagna, Italy
Istituto Nazionale Tumori, Sarcoma Unit, Milano, Lombardia, Italy
Erasmus Mc - Daniel Den Hoed Kliniek; Medical Oncology, Rotterdam, , Netherlands
Norwegian Radium Hospital, Oslo, , Norway
Hospital Sant Joan De Deu, Esplugues De Llobregas, Barcelona, Spain
Skånes University Hospital, Skånes Department of Onclology, Lund, , Sweden
UCL Hospital NHS Trust, London, , United Kingdom
Royal Marsden Hospital; Dept of Med-Onc, London, , United Kingdom
Christie Hospital NHS Trust, Manchester, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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