Spots Global Cancer Trial Database for Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma
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Trial Identification
Brief Title: Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma
Official Title: LABORATORY STUDIES OF SOFT TISSUE SARCOMAS
Study ID: NCT00900341
Conditions
Study Description
Brief Summary: RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.
Detailed Description: OBJECTIVES: * To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS). * To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies. * To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens. * To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study. OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States
Contact Details
Name: Lee D. Cranmer, MD, PhD
Affiliation: University of Arizona
Role: PRINCIPAL_INVESTIGATOR
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