Spots Global Cancer Trial Database for Protein Expression in Samples From Young Patients With Rhabdomyosarcoma

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Trial Identification

Brief Title: Protein Expression in Samples From Young Patients With Rhabdomyosarcoma

Official Title: Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)

Study ID: NCT01426945

Conditions

Sarcoma

Interventions

protein expression analysis

immunohistochemistry staining method

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.

Detailed Description: OBJECTIVES: * To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples. OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.