Spots Global Cancer Trial Database for S0344 Intralesional Resection in Treating Patients With Chondrosarcoma of the Bone
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Trial Identification
Brief Title: S0344 Intralesional Resection in Treating Patients With Chondrosarcoma of the Bone
Official Title: A Phase II Surgical Trial Of Intralesional Resection Of Low-Grade Intracompartmental Chondrosarcoma Of Bone
Study ID: NCT00096213
Conditions
Interventions
Study Description
Brief Summary: RATIONALE: Intralesional resection is a less invasive type of surgery for chondrosarcoma of the bone and may have fewer side effects and improve recovery. PURPOSE: This phase II trial is studying how well intralesional resection works in treating patients with low-grade chondrosarcoma of the bone.
Detailed Description: OBJECTIVES: * Determine the probability of local complications (e.g., fracture, nerve palsy, deep venous thrombosis, unexpected rehospitalization, unanticipated reoperation, or death within 2 years) in patients with suspected low-grade intracompartmental chondrosarcoma of the bone undergoing intralesional resection. * Determine the 5-year probability of local recurrence and development of metastatic disease in patients undergoing this procedure. * Determine the impact of musculoskeletal tumor reconstruction on the functional status of patients undergoing this procedure. OUTLINE: This is a multicenter study. Patients undergo intralesional resection (curettage with high-speed burr). Patients then receive local adjuvant treatment comprising liquid nitrogen, phenol, alcohol, or argon beam to the excision site. The bone cavity is then filled with either polymethyacrylate cement or a bone graft (allograft or homograft). Patients may also have a metal plate installed at the wound site. Patients are followed every 3 months for 1 year and then every 6 months for 4 years. PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 30-60 months.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center, Aurora, Colorado, United States
University of Florida Shands Cancer Center, Gainesville, Florida, United States
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States
William Beaumont Hospital - Royal Oak Campus, Royal Oak, Michigan, United States
University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico, United States
Akron City Hospital, Akron, Ohio, United States
Oregon Health & Science University Cancer Institute, Portland, Oregon, United States
Presbyterian Hospital of Dallas, Dallas, Texas, United States
Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, United States
St. Joseph Cancer Center, Bellingham, Washington, United States
Olympic Hematology and Oncology, Bremerton, Washington, United States
Skagit Valley Hospital Cancer Care Center, Mt. Vernon, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Harborview Medical Center, Seattle, Washington, United States
Minor and James Medical, PLLC, Seattle, Washington, United States
Group Health Central Hospital, Seattle, Washington, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States
Polyclinic First Hill, Seattle, Washington, United States
University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States
North Puget Oncology at United General Hospital, Sedro-Wooley, Washington, United States
Cancer Care Northwest - Spokane South, Spokane, Washington, United States
Wenatchee Valley Medical Center, Wenatchee, Washington, United States
Contact Details
Name: R. Lor Randall, MD, FACS
Affiliation: University of Utah
Role: STUDY_CHAIR
Name: Janet S. Biermann, MD
Affiliation: University of Michigan Rogel Cancer Center
Role: STUDY_CHAIR
Name: Edward Cheng, MD
Affiliation: Masonic Cancer Center, University of Minnesota
Role: STUDY_CHAIR
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