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Spots Global Cancer Trial Database for Paclitaxel in Treating Patients With Recurrent or Persistent Cancer of the Uterus

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Trial Identification

Brief Title: Paclitaxel in Treating Patients With Recurrent or Persistent Cancer of the Uterus

Official Title: Evaluation of Paclitaxel (Taxol) in the Treatment of Recurrent or Persistent Leiomyosarcoma of the Uterus

Study ID: NCT00003054

Conditions

Sarcoma

Interventions

paclitaxel

Study Description

Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with recurrent or persistent cancer of the uterus.

Detailed Description: OBJECTIVES: I. Estimate the antitumor activity of paclitaxel in patients with metastatic or persistent leiomyosarcoma of the uterus who have failed treatment protocols of higher priority. II. Determine the nature and degree of toxic effects of paclitaxel in this group of patients. OUTLINE: Patients receive a continuous infusion of paclitaxel once every 3 weeks over 3 hours. Patients in complete remission, partial remission, or stable disease undergo at least 3 courses of paclitaxel. Paclitaxel continues until disease progression or adverse effects prohibit further treatment. All patients are followed until death. PROJECTED ACCRUAL: This study anticipates an annual accrual of approximately 25 patients over 2.5 years.

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Alabama Comprehensive Cancer Center, Birmingham, Alabama, United States

CCOP - Greater Phoenix, Phoenix, Arizona, United States

USC/Norris Comprehensive Cancer Center, Los Angeles, California, United States

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

Chao Family Comprehensive Cancer Center, Orange, California, United States

Women's Cancer Center, Palo Alto, California, United States

University of Colorado Cancer Center, Denver, Colorado, United States

Vincent T. Lombardi Cancer Research Center, Georgetown University, Washington, District of Columbia, United States

Walter Reed Army Medical Center, Washington, District of Columbia, United States

H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States

Emory University Hospital - Atlanta, Atlanta, Georgia, United States

Medical College of Georgia Comprehensive Cancer Center, Augusta, Georgia, United States

MBCCOP - Hawaii, Honolulu, Hawaii, United States

Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, United States

University of Chicago Cancer Research Center, Chicago, Illinois, United States

CCOP - Evanston, Evanston, Illinois, United States

CCOP - Central Illinois, Springfield, Illinois, United States

Indiana University Cancer Center, Indianapolis, Indiana, United States

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky, United States

Johns Hopkins Oncology Center, Baltimore, Maryland, United States

Medicine Branch, Bethesda, Maryland, United States

Radiation Oncology Branch, Bethesda, Maryland, United States

University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, United States

CCOP - Ann Arbor Regional, Ann Arbor, Michigan, United States

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

CCOP - Kansas City, Kansas City, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

CCOP - Montana Cancer Consortium, Billings, Montana, United States

CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska, United States

CCOP - Southern Nevada Cancer Research Foundation, Las Vegas, Nevada, United States

Cooper Hospital/University Medical Center, Camden, New Jersey, United States

Cancer Center of Albany Medical Center, Albany, New York, United States

State University of New York Health Science Center at Brooklyn, Brooklyn, New York, United States

North Shore University Hospital, Manhasset, New York, United States

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

University of Rochester Cancer Center, Rochester, New York, United States

State University of New York Health Sciences Center - Stony Brook, Stony Brook, New York, United States

Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, North Carolina, United States

Duke Comprehensive Cancer Center, Durham, North Carolina, United States

Brookview Research, Inc., Winston-Salem, North Carolina, United States

Comprehensive Cancer Center of Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, United States

Barrett Cancer Center, The University Hospital, Cincinnati, Ohio, United States

Ireland Cancer Center, Cleveland, Ohio, United States

Cleveland Clinic Cancer Center, Cleveland, Ohio, United States

Arthur G. James Cancer Hospital - Ohio State University, Columbus, Ohio, United States

University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, United States

CCOP - St. Francis Hospital/Natalie Warren Bryant Cancer Center, Tulsa, Oklahoma, United States

CCOP - Columbia River Program, Portland, Oregon, United States

Abington Memorial Hospital, Abington, Pennsylvania, United States

Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States

University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, United States

Kimmel Cancer Center of Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States

Pennsylvania Hospital, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Medical University of South Carolina, Charleston, South Carolina, United States

CCOP - Upstate Carolina, Spartanburg, South Carolina, United States

CCOP - Baptist Cancer Institute, Memphis, Tennessee, United States

Simmons Cancer Center - Dallas, Dallas, Texas, United States

University of Texas - MD Anderson Cancer Center, Houston, Texas, United States

Cancer Center, University of Virginia HSC, Charlottesville, Virginia, United States

University of Washington Medical Center, Seattle, Washington, United States

Tacoma General Hospital, Tacoma, Washington, United States

NCIC-Clinical Trials Group, Kingston, Ontario, Canada

Contact Details

Name: Donald G. Gallup, MD

Affiliation: Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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