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Brief Title: Phase 2b Study of GC4711 in Combination With SBRT for Nonmetastatic Pancreatic Cancer
Official Title: GRECO-2: A Randomized, Phase 2b Study of GC4711 in Combination With Stereotactic Body Radiation Therapy (SBRT) in the Treatment of Unresectable or Borderline Resectable Nonmetastatic Pancreatic Cancer
Study ID: NCT04698915
Brief Summary: GTI-4711-201 is designed as a Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to determine the effect to OS by adding GC4711 to SBRT following chemotherapy in patients with unresectable or borderline resectable nonmetastatic
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
Cedars-Sinai Medical Center, Los Angeles, California, United States
University of Miami, Miami, Florida, United States
Orlando Health Cancer Institute, Orlando, Florida, United States
Moffitt Cancer Center, Tampa, Florida, United States
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States
University of Kansas Medical Center, Kansas City, Kansas, United States
Henry Ford Hospital, Detroit, Michigan, United States
Mayo Clinic Rochester, Rochester, Minnesota, United States
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
Hackensack Meridian Health, Hackensack, New Jersey, United States
Northwell Health, Lake Success, New York, United States
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Duke University Medical Center, Durham, North Carolina, United States
University Hospitals of Cleveland, Cleveland, Ohio, United States
Radiation Oncology and Gamma Knife Center of Oregon, Portland, Oregon, United States
Pennsylvania State University, University Park, Pennsylvania, United States
UT Southwestern Medical, Dallas, Texas, United States
MD Anderson Cancer Center, Houston, Texas, United States
University of Washington Medical Center (UWMC) - Radiation Oncology Center, Seattle, Washington, United States
Cancer Care Northwest, Spokane Valley, Washington, United States
London Regional Cancer Center, London, Ontario, Canada
Jewish General Hospital, Montréal, Quebec, Canada
Atlantic Clinical Cancer Research Unit/QEII Health Sciences Centre, Halifax, Nova Scotia, , Canada
Institut Bergonié, Bordeaux, , France
CHRU de Brest Hôpital Morvan, Brest, , France
Centre Georges François Leclerc, Dijon, , France
Institut régional du Cancer de Montpellier, Montpellier, , France
Tenon Hospital, Paris, , France
CHU de Bordeaux, Hôpital Haut-Lévêque, Pessac, , France
Aberdeen Royal Infirmary, Aberdeen, Aberdeenshire, United Kingdom
GenesisCare, Oxford, Oxfordshire, United Kingdom
Addenbrookes Hospital, Cambridge, , United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Imperial College London, Saint Mary's Hospital, London, , United Kingdom