Spots Global Cancer Trial Database for Novel Imaging Markers in SPMS
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Trial Identification
Brief Title: Novel Imaging Markers in SPMS
Official Title: Novel Imaging Markers of Innate Immune Activation in Secondary Progressive Multiple Sclerosis
Study ID: NCT05357833
Study Description
Brief Summary: This pilot study takes the innovative approach of using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI to measure activity of the innate immune system within MS lesions. Activity of innate immunity has been hypothesized as one of the critical pathologic processes underpinning neurologic worsening in progressive MS. As such, in the short term this project proposes to investigate USPIO uptake in SPMS lesions as a promising in vivo imaging biomarker for chronic-active lesions, as distinguished from chronic-inactive lesions.
Detailed Description:
Eligibility
Minimum Age: 35 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Utah Health Imaging and Neurosciences Center, Salt Lake City, Utah, United States
Contact Details
Name: M. Mateo Paz Soldan, MD, PhD
Affiliation: University of Utah
Role: PRINCIPAL_INVESTIGATOR
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