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Spots Global Cancer Trial Database for A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies

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Trial Identification

Brief Title: A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies

Official Title: A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Subjects With Select Advanced Malignancies

Study ID: NCT02118337

Study Description

Brief Summary: To evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with Durvalumab versus Nivolumab Monotherapy in Participants with Select Advanced Malignancies.

Detailed Description: This is a multicenter, open-label, Phase 1/2 study to evaluate the safety, tolerability, PK, immunogenicity, and antitumor activity of MEDI0680 in combination with durvalumab or nivolumab monotherapy in adult immunotherapy-naïve participants with selected advanced malignancies.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Research Site, Los Angeles, California, United States

Research Site, Tampa, Florida, United States

Research Site, Overland Park, Kansas, United States

Research Site, Louisville, Kentucky, United States

Research Site, Rochester, Minnesota, United States

Research Site, Hackensack, New Jersey, United States

Research Site, New York, New York, United States

Research Site, Cleveland, Ohio, United States

Research Site, Oklahoma City, Oklahoma, United States

Research Site, Portland, Oregon, United States

Research Site, Hershey, Pennsylvania, United States

Research Site, Nashville, Tennessee, United States

Research Site, Seattle, Washington, United States

Research Site, East Bentleigh, , Australia

Research Site, Frankston, , Australia

Research Site, Toronto, Ontario, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Bordeaux, , France

Research Site, Dijon, , France

Research Site, Marseille, , France

Research Site, Paris Cedex 15, , France

Research Site, Villejuif, , France

Research Site, Amsterdam, , Netherlands

Research Site, Groningen, , Netherlands

Research Site, Cambridge, , United Kingdom

Research Site, Cardiff, , United Kingdom

Research Site, Southampton, , United Kingdom

Contact Details

Name: Laura Chow, MD

Affiliation: University of Washington

Role: PRINCIPAL_INVESTIGATOR

Name: Omid Hamid, MD

Affiliation: The Angeles Clinic

Role: PRINCIPAL_INVESTIGATOR

Name: Jhanelle Gray, MD

Affiliation: Moffitt Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Rachel Sanborn, MD

Affiliation: Providence Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Mohamad Salkeni, MD

Affiliation: Mary Babb Randolph Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Monika Joshi, MD

Affiliation: Penn State Hershey Cancer Institute

Role: PRINCIPAL_INVESTIGATOR

Name: Robert Alter, MD

Affiliation: John Theurer Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Raid Aljumaily, MD

Affiliation: Peggy Charles Stephenson Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Jason Chesney, MD

Affiliation: Brown Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Fernando Quevedo, MD

Affiliation: Mayo Clinic

Role: PRINCIPAL_INVESTIGATOR

Name: Martin Voss, MD

Affiliation: Memorial Sloan Kettering Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Name: Johanna Bendell

Affiliation: SCRI Development Innovations, LLC

Role: PRINCIPAL_INVESTIGATOR

Name: Elizabeth Henry

Affiliation: Loyola Univ. Medical Center

Role: PRINCIPAL_INVESTIGATOR

Name: Lionel Lewis

Affiliation: Dartmouth-Hitchcock Medical Center

Role: PRINCIPAL_INVESTIGATOR

Name: Brian Rini

Affiliation: The Cleveland Clinic

Role: PRINCIPAL_INVESTIGATOR

Name: Peter Van Veldhuizen

Affiliation: Menorah Medical Center tour

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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