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Brief Title: A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies
Official Title: A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Subjects With Select Advanced Malignancies
Study ID: NCT02118337
Brief Summary: To evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with Durvalumab versus Nivolumab Monotherapy in Participants with Select Advanced Malignancies.
Detailed Description: This is a multicenter, open-label, Phase 1/2 study to evaluate the safety, tolerability, PK, immunogenicity, and antitumor activity of MEDI0680 in combination with durvalumab or nivolumab monotherapy in adult immunotherapy-naïve participants with selected advanced malignancies.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Research Site, Los Angeles, California, United States
Research Site, Tampa, Florida, United States
Research Site, Overland Park, Kansas, United States
Research Site, Louisville, Kentucky, United States
Research Site, Rochester, Minnesota, United States
Research Site, Hackensack, New Jersey, United States
Research Site, New York, New York, United States
Research Site, Cleveland, Ohio, United States
Research Site, Oklahoma City, Oklahoma, United States
Research Site, Portland, Oregon, United States
Research Site, Hershey, Pennsylvania, United States
Research Site, Nashville, Tennessee, United States
Research Site, Seattle, Washington, United States
Research Site, East Bentleigh, , Australia
Research Site, Frankston, , Australia
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Bordeaux, , France
Research Site, Dijon, , France
Research Site, Marseille, , France
Research Site, Paris Cedex 15, , France
Research Site, Villejuif, , France
Research Site, Amsterdam, , Netherlands
Research Site, Groningen, , Netherlands
Research Site, Cambridge, , United Kingdom
Research Site, Cardiff, , United Kingdom
Research Site, Southampton, , United Kingdom
Name: Laura Chow, MD
Affiliation: University of Washington
Role: PRINCIPAL_INVESTIGATOR
Name: Omid Hamid, MD
Affiliation: The Angeles Clinic
Role: PRINCIPAL_INVESTIGATOR
Name: Jhanelle Gray, MD
Affiliation: Moffitt Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Rachel Sanborn, MD
Affiliation: Providence Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Mohamad Salkeni, MD
Affiliation: Mary Babb Randolph Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Monika Joshi, MD
Affiliation: Penn State Hershey Cancer Institute
Role: PRINCIPAL_INVESTIGATOR
Name: Robert Alter, MD
Affiliation: John Theurer Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Raid Aljumaily, MD
Affiliation: Peggy Charles Stephenson Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Jason Chesney, MD
Affiliation: Brown Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Fernando Quevedo, MD
Affiliation: Mayo Clinic
Role: PRINCIPAL_INVESTIGATOR
Name: Martin Voss, MD
Affiliation: Memorial Sloan Kettering Cancer Center
Role: PRINCIPAL_INVESTIGATOR
Name: Johanna Bendell
Affiliation: SCRI Development Innovations, LLC
Role: PRINCIPAL_INVESTIGATOR
Name: Elizabeth Henry
Affiliation: Loyola Univ. Medical Center
Role: PRINCIPAL_INVESTIGATOR
Name: Lionel Lewis
Affiliation: Dartmouth-Hitchcock Medical Center
Role: PRINCIPAL_INVESTIGATOR
Name: Brian Rini
Affiliation: The Cleveland Clinic
Role: PRINCIPAL_INVESTIGATOR
Name: Peter Van Veldhuizen
Affiliation: Menorah Medical Center tour
Role: PRINCIPAL_INVESTIGATOR