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Spots Global Cancer Trial Database for Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma

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Trial Identification

Brief Title: Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma

Official Title: FDG PET-CT Based Risk Adapted Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma: A Prospective Randomised Controlled Trial

Study ID: NCT05142982

Conditions

Seminoma

Interventions

Radiotherapy

Study Description

Brief Summary: Testicular tumors account for 1% of all cancers in males and germ cell tumors comprise 95% of all testicular cancers. Seminomas consist of around 50% of cases. However,adequate information is not there as 60- 80% residual disease is seen even after with the standard management of chemotherapy. With the advent of functional imaging there was hope that it could aid in more accurately targeting these tumors to systematically evaluate the role of PET-CT imaging in identifying patients diagnosed with stage IIB-IIIC seminomatous germ cell tumor, with residual visible tumor post chemotherapy who would benefit with loco regional radiotherapy. The therapeutic research in Seminomashas been relatively slow and such structured studies can allow analysis of large number of patients to report on acute and late effect of treatment outcomes using CTCAE and QOL (EORTC QLQ C-30) in these cancers. We hope that we will get help in identifying thrust areas for future research through this study.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: MALE

Healthy Volunteers: No

Locations

Tata Memorial Centre, Mumbai, Maharashtra, India

Dr Vedang Murthy, Navi-Mumbai, Maharashtra, India

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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