Spots Global Cancer Trial Database for Skin Toxicity in Patients With Metastatic Colorectal Cancer Treated With Anti-EGFR and Chemotherapy (DERMIA)
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Trial Identification
Brief Title: Skin Toxicity in Patients With Metastatic Colorectal Cancer Treated With Anti-EGFR and Chemotherapy (DERMIA)
Official Title: Phase II Clinical Trial of Doxycycline 50 mg or 100 mg Daily for the Prevention of Skin Toxicity in Patients With Metastatic Colorectal Cancer Treated With Anti-EGFR and Chemotherapy
Study ID: NCT03448731
Conditions
Interventions
Study Description
Brief Summary: Clinical evidence has suggested that sub-antimicrobial doses of doxycycline may have the potential to treat inflammatory lesions of acne. The efficacy of doses below 100 mg/day of doxycycline in the prevention of skin toxicity in patients with treated with Epidermal Growth Factor Receptor (EGFR)-targeted therapies has never been studied. Therefore, the aim of the present study is to describe the efficacy of doxycycline 50 or 100 mg per day in the prevention of skin toxicity in patients with metastatic Colorectal cancer (mCRC) treated with anti-EGFR in combination with chemotherapy.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Hospital Punta Europa, Algeciras, , Spain
Hospital Puerta del Mar, Cadiz, , Spain
Hospital Puerto Real, Cadiz, , Spain
Hospital San Pedro de Alcántara, Cáceres, , Spain
Hospital Clinico San Cecilio, Granada, , Spain
Hospital Juan Ramón Jiménez, Huelva, , Spain
Hospital de Jerez, Jerez De La Frontera, , Spain
Hospital Virgen Macarena, Sevilla, , Spain
Contact Details
Name: Patricia Ramirez-Daffós, MD
Affiliation: Hospital Universitario Puerta del Mar
Role: PRINCIPAL_INVESTIGATOR
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