Spots Global Cancer Trial Database for Multi-parametric Imaging in Personalized Radiotherapy

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Trial Identification

Brief Title: Multi-parametric Imaging in Personalized Radiotherapy

Official Title: A Technical Framework for Combining Multi-parametric Imaging With Advanced Modelling in Personalized Radiotherapy

Study ID: NCT05888064

Conditions

Skull Base Chordoma

Interventions

diffusion MRI sequences

Study Description

Brief Summary: The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.

Detailed Description: The study design consists of the retrospective collection of routinely-acquired data (CT, MRI and dose maps, along with relevant clinical information) and the prospective acquisition of optimized non-invasive MR imaging data, of skull-based chordoma patients treated with particle therapy (PT) at the National Center for Oncological Hadrontherapy (CNAO, Pavia, Italy). This data will be stored in a proper repository under CNAO's control, shared with Politecnico di Milano through encrypted channels, and it will be used to implement mathematical models able to predict treatment outcome at different scales (macroscopic, microscopic and radiobiological).