Spots Global Cancer Trial Database for Picoplatin as Second-Line Therapy for Patients With Small Cell Lung Cancer
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Trial Identification
Brief Title: Picoplatin as Second-Line Therapy for Patients With Small Cell Lung Cancer
Official Title: A Phase II Study of Picoplatin as Second-Line Therapy for Subjects With Resistant or Refractory Small Cell Lung Cancer
Study ID: NCT00116610
Conditions
Interventions
Study Description
Brief Summary: This is a Phase II research study that is designed for patients who have small cell lung cancer (SCLC) that is no longer responding to treatment. Patients will receive picoplatin, a new platinum-based agent that is currently under investigation, in 21-day cycles.
Detailed Description: Platinum drugs work by binding to DNA and preventing the rapid cell division of tumors. However, many tumors demonstrate a resistance to platinum drugs. Results from preclinical studies indicate that picoplatin (previously called AMD473 or ZD0473) may be able to overcome or partially overcome platinum resistance. More than 500 patients have received picoplatin in previous Phase I or Phase II clinical trials.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Genesis Cancer Center, Hot Springs, Arkansas, United States
Study Site, Los Angeles, California, United States
Comprehensive Cancer Center, Palm Springs, California, United States
Eastern Connecticut Hematology/Oncology, Norwich, Connecticut, United States
Oncology Hematology Group of South Florida, Miami, Florida, United States
H. Lee Moffitt Cancer Center, Tampa, Florida, United States
Augusta Oncology Associates, Augusta, Georgia, United States
Central Georgia Hematology Oncology Associates, Macon, Georgia, United States
Georgia Cancer Specialists, Tucker, Georgia, United States
Rush Medical College, Chicago, Illinois, United States
Medical Center of Vincennes, Vincennes, Indiana, United States
University of Kansas Medical Center, Kansas City, Kansas, United States
Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States
The Ochsner Clinic, New Orleans, Louisiana, United States
Louisiana State University Health Science Center, Shreveport, Louisiana, United States
University of Missouri / Ellis Fischel Cancer Center, Columbia, Missouri, United States
The Center for Cancer Care & Research, St. Louis, Missouri, United States
Hematology Oncology Centers of the Northern Rockies, Billings, Montana, United States
V.A. Sierra Nevada Health Care, Reno, Nevada, United States
Dartmouth-Hitchcock Medical Center Hematology/Oncology, Lebanon, New Hampshire, United States
Mt. Sinai Medical Center, New York, New York, United States
Southeastern Medical Oncology Center, Goldsboro, North Carolina, United States
Providence Portland Medical Center, Portland, Oregon, United States
Consultants in Medical Oncology & Hematology, Drexel Hill, Pennsylvania, United States
South Carolina Oncology Associates, PA, Columbia, South Carolina, United States
The West Clinic, Memphis, Tennessee, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Southwest Regional Cancer Center, Austin, Texas, United States
Tom Baker Cancer Center, Calgary, Alberta, Canada
Princess Margaret Hospital, Toronto, Ontario, Canada
, Stepanovskoye, Krasnogorskiy District, Moscow Region, Russian Federation
, Ufa, Republic of Bashkortostan, Russian Federation
, Petrozavodsk, Republic of Karelia, Russian Federation
, Kazan, Republic of Tatarstan, Russian Federation
, Izhevsk, Republic of Udmurtia, Russian Federation
, Engels, Saratov Region, Russian Federation
, Cherepovets, Vologodskaya Region, Russian Federation
, Astrakhan, , Russian Federation
, Barnaul, , Russian Federation
, Chelyabinsk, , Russian Federation
, Ekaterinburg, , Russian Federation
, Kaliningrad, , Russian Federation
, Krasnodar, , Russian Federation
, Moscow, , Russian Federation
, Nizhny Novgorod, , Russian Federation
, Omsk, , Russian Federation
, Orenburg, , Russian Federation
, Pyatigorsk, , Russian Federation
, Rostov-na-Donu, , Russian Federation
, Samara, , Russian Federation
, St. Petersburg, , Russian Federation
, Stavropol, , Russian Federation
, Ulyanovsk, , Russian Federation
, Voronezh, , Russian Federation
, Yaroslavl, , Russian Federation
Contact Details
Name: Hazel Breitz, MD
Affiliation: Poniard Pharmaceuticals
Role: STUDY_DIRECTOR
Name: Paul Weiden, MD
Affiliation: Poniard Pharmaceuticals
Role: STUDY_DIRECTOR
Name: David Karlin, MD
Affiliation: Poniard Pharmaceuticals
Role: STUDY_DIRECTOR
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