Spots Global Cancer Trial Database for Bevacizumab in Extensive Small Cell Lung Cancer
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Trial Identification
Brief Title: Bevacizumab in Extensive Small Cell Lung Cancer
Official Title: Randomized Phase II-III Study of Bevacizumab 7,5 mg/kg in Combination With Chemotherapy Versus Chemotherapy in Extensive-Disease Small-Cell Lung Cancer After Response to Chemotherapy : PCDE (cisPlatin - Cyclophosphamide - epiDoxorubicin - Etoposide) or PE (cisPlatin - Etoposide)
Study ID: NCT00930891
Conditions
Study Description
Brief Summary: Despite the fact that a substantial response rate may be obtained in small-cell lung cancers (using double-drug chemotherapy: cisplatin-etoposide, PE), a cure remains an exception. More aggressive regimens remain controversial and recent attempts at increasing dose-intensity have been restricted to patients with a more favourable presentation. Bevacizumab is a humanized monoclonal antibody which binds to VEGF (Vascular Endothelial Growth Factor). In association with double-drug standard chemotherapies, it has been proven that bevacizumab can improve survival of previously untreated advanced non-small-cell lung cancers (NSCLC), compared to chemotherapy without bevacizumab). Such promising effects on NSCLC deserve to be tested on small-cell lung cancers. In this trial (IFCT-0802), standard chemotherapy (PCDE or PE) will be compared to experimental treatment (PCDE or PE + bevacizumab 7.5 mg/kg) for previously untreated SCLC patients.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Annemasse - CH, Ambilly, , France
Angers - CHU, Angers, , France
Armentières - CH, Armentières, , France
CHU Besancon - Pneumologie, Besancon, , France
Centre F. Baclesse, Caen, , France
CHU - Pneumologie, Caen, , France
Cahors - CH, Cahors, , France
Chalons-en-Champagne - CH, Chalons-en-Champagne, , France
Chauny - CH, Chauny, , France
Hôpital Percy-Armées - Pneumologie, Clamart, , France
Clermont Ferrand - CHU, Clermont Ferrand, , France
Colmar - CH, Colmar, , France
CH - Compiègne, Compiègne, , France
Créteil - CHI, Créteil, , France
Dijon - CAC, Dijon, , France
Dijon - CHU, Dijon, , France
Draguignan - CH, Draguignan, , France
CHU Grenoble - pneumologie, Grenoble, , France
Harfleur - Clinique du Petit Colmoulins, Harfleur, , France
Saint Omer - CHI, Helfaut, , France
Jonzac - CH, Jonzac, , France
Chartres - CH, Le Coudray, , France
Centre Hospitalier - Pneumologie, Le Mans, , France
CH, Longjumeau, , France
APHM - Hôpital Sainte Marguerite, Marseille, , France
Marseille - CRLCC, Marseille, , France
Maubeuge - Polyclinique du Parc, Maubeuge, , France
Meaux - CH, Meaux, , France
Metz - CHR, Metz, , France
Mont de Marsan - CH, Mont de Marsan, , France
Montpellier - CHRU, Montpellier, , France
Mulhouse - CH, Mulhouse, , France
Neuilly - Hôpital Américain de Paris, Neuilly, , France
Nevers - CH, Nevers, , France
Nice - CAC, Nice, , France
Orléans - CH, Orléans, , France
APHP - Saint-Antoine - pneumologie, Paris, , France
APHP - Hopital Tenon - Pneumologie, Paris, , France
Pau - CH, Pau, , France
HCL - Lyon Sud (Pneumologie), Pierre Bénite, , France
Reims - CHU, Reims, , France
Reims - CRLCC, Reims, , France
Rouen - CHU, Rouen, , France
Saint Brieuc - CHG, Saint Brieuc, , France
Saint Nazaire - Centre Etienne Dolet, Saint Nazaire, , France
Saint Priest en Jarez - ICL, Saint Priest en Jarez, , France
Saint Quentin - CH, Saint Quentin, , France
Saverne - CH, Saverne, , France
Senlis - CH, Senlis, , France
Nouvel Hopital Civil - Pneumologie, Strasbourg, , France
Suresnes - Hopital Foch, Suresnes, , France
Thonon les bains, Thonon les bains, , France
Toulon - HIA, Toulon, , France
CHU Toulouse - Pneumologie, Toulouse, , France
Toulouse - Clinique Pasteur, Toulouse, , France
Tours - CHU, Tours, , France
Nancy - CHU, Vandoeuvre lès Nancy, , France
Verdun - CHG, Verdun, , France
Vesoul - CHI, Vesoul, , France
Institut Gustave Roussy, Villejuif, , France
Contact Details
Name: Jean-Louis PUJOL, Pr
Affiliation: CHRU Montpellier
Role: PRINCIPAL_INVESTIGATOR
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