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Spots Global Cancer Trial Database for A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

Official Title: Open-Label Phase 2 Study of Ladiratuzumab Vedotin (LV) for Unresectable Locally Advanced or Metastatic Solid Tumors

Study ID: NCT04032704

Study Description

Brief Summary: This trial will study ladiratuzumab vedotin (LV) alone and with pembrolizumab to find out if it works to treat different types of solid tumors. It will also find out what side effects may occur. A side effect is anything the drug does besides treating cancer.

Detailed Description: This trial is designed to assess the antitumor activity, safety, and tolerability of LV alone and with pembrolizumab, for the treatment of solid tumors. Participants with the following advanced solid tumors will be enrolled: Cohort 1: small cell lung cancer (SCLC) Cohort 2: non-small cell lung cancer-squamous (NSCLC-squamous) Cohort 3: non-small cell lung cancer-nonsquamous (NSCLC-nonsquamous) Cohort 4: head and neck squamous cell carcinoma (HNSCC) Cohort 5: esophageal squamous cell carcinoma (esophageal-squamous) Cohort 6: gastric and gastroesophageal junction (GEJ) adenocarcinoma Cohort 7: castration-resistant prostate cancer (CRPC) Cohort 8: melanoma Participants will continue to receive study treatment until disease progression, unacceptable toxicity, investigator decision, consent withdrawal, study termination by the sponsor, pregnancy, or death, whichever comes first.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Ironwood Cancer & Research Centers - Chandler, Chandler, Arizona, United States

Adventist Health White Memorial, Los Angeles, California, United States

Providence Medical Foundation, Santa Rosa, California, United States

Eastern CT Hematology and Oncology Associates, Norwich, Connecticut, United States

GenesisCare USA, Jacksonville, Florida, United States

AdventHealth Cancer Institute, Orlando, Florida, United States

IACT Health, Columbus, Georgia, United States

Northwestern University, Chicago, Illinois, United States

Decatur Memorial Hospital - Illinois, Decatur, Illinois, United States

Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana, United States

University of Maryland, Baltimore, Maryland, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

HealthPartners Institute, Saint Louis Park, Minnesota, United States

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

Valley Hospital, The / Luckow Pavilion, Paramus, New Jersey, United States

San Juan Oncology Associates, Farmington, New Mexico, United States

Weill Cornell Medicine, New York, New York, United States

Stony Brook University Cancer Center, Stony Brook, New York, United States

FirstHealth of the Carolinas, Pinehurst, North Carolina, United States

Gabrail Cancer Center Research, LLC, Canton, Ohio, United States

Providence Portland Medical Center, Portland, Oregon, United States

Saint Francis Hospital / Bon Secours - South Carolina, Greenville, South Carolina, United States

Erlanger Oncology and Hematology, Chattanooga, Tennessee, United States

Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville, Tennessee, United States

Joe Arrington Cancer Research and Treatment Center, Lubbock, Texas, United States

UT Health East Texas Hope Cancer Center, Tyler, Texas, United States

Carbone Cancer Center / University of Wisconsin, Madison, Wisconsin, United States

Flinders Medical Centre, Bedford Park, Other, Australia

Townsville Cancer Center, Douglas, Other, Australia

Peninsula and South East Oncology, Frankston, Other, Australia

Central Coast Local Health District (Gosford and Wyong Hospitals), Gosford, Other, Australia

Royal Hobart Hospital, Hobart, Other, Australia

Cabrini, Malvern, Other, Australia

St Vincents Hospital Sydney, Sydney, Other, Australia

Melanoma Institute Australia, Wollstonecraft, Other, Australia

Azienda Ospedaliero-Universitaria di Bologna Policlinico S. Orsola-Malpighi, Bologna, Other, Italy

Azienda Ospedaliero Universitaria Careggi, Firenze, Other, Italy

ASL 3 Genovese Villa Scassi Hospital, Genova, Other, Italy

San Luca Hospital, Lucca, Other, Italy

Irccs Irst, Meldola, Other, Italy

Istituto Europeo di Oncologia, Milano, Other, Italy

Niguarda Ca' Granda Hospital, Milan, Other, Italy

Fondazione IRCCS San Gerardo dei Tintori, Monza, Other, Italy

Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Other, Italy

Policlinico Universitario Agostino Gemelli, Roma, Other, Italy

AOUS Policlinico Le Scotte, Siena, Other, Italy

Dong-A University Hospital, Busan, Other, Korea, Republic of

Chonnam National University Hwasun Hospital, Hwasun, Other, Korea, Republic of

Seoul National University Bundang Hospital, Seongnam-si, Other, Korea, Republic of

Seoul National University Hospital, Seoul, Other, Korea, Republic of

Severance Hospital, Yonsei University Health System, Seoul, Other, Korea, Republic of

Samsung Medical Center, Seoul, Other, Korea, Republic of

Seoul National University Boramae Medical Center, Seoul, Other, Korea, Republic of

Korea University Guro Hospital, Seoul, Other, Korea, Republic of

St. Vincent's Hospital, The Catholic University of Korea, Suwon-si, Other, Korea, Republic of

Ajou University Hospital, Suwon-si, Other, Korea, Republic of

Taichung Veterans General Hospital, Taichung, Other, Taiwan

National Cheng-Kung University Hospital, Tainan, Other, Taiwan

National Taiwan University Hospital, Taipei, Other, Taiwan

Taipei Medical University Hospital, Taipei, Other, Taiwan

The Beatson West of Scotland Cancer Centre, Glasgow, Other, United Kingdom

The Royal Marsden Hospital, London, Other, United Kingdom

Sarah Cannon Research Institute UK, London, Other, United Kingdom

UCL Cancer Institute, London, Other, United Kingdom

The Christie NHS Foundation Trust, Manchester, Other, United Kingdom

The Royal Marsden Hospital (Surrey), Sutton, Other, United Kingdom

Contact Details

Name: Brandon Croft, PharmD

Affiliation: Seagen Inc.

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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