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Spots Global Cancer Trial Database for Irinotecan, Carboplatin, and Sunitinib in First Line Extensive-Stage Small Cell Lung Cancer

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Trial Identification

Brief Title: Irinotecan, Carboplatin, and Sunitinib in First Line Extensive-Stage Small Cell Lung Cancer

Official Title: Phase II Study of Irinotecan, Carboplatin, and Sunitinib in the First Line Treatment of Extensive-Stage Small Cell Lung Cancer

Study ID: NCT00695292

Study Description

Brief Summary: This proposed Phase II trial will investigate the combination of irinotecan and carboplatin followed by sunitinib in the first-line treatment of patients with extensive-stage SCLC.

Detailed Description: Irinotecan/platinum regimens are emerging as standard treatments for patients with extensive-stage disease. The irinotecan/carboplatin doses that will be used in this study have been used in two previous Phase II SCLC trials, and were found to be extremely well tolerated (Thompson et al. 2005; Spigel et al. 2007). Adding a novel, minimally toxic agent to this regimen may further enhance efficacy in this patient population without contributing to toxicity. This trial will evaluate the use of sunitinib following 6 cycles of treatment with chemotherapy in the treatment of SCLC. The trial will be performed under the leadership of SCRI, a community-based, multi-center, clinical trial organization.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Florida Cancer Specialists, Fort Myers, Florida, United States

Florida Hospital Cancer Insitute, Orlando, Florida, United States

Northeast Georgia Medical Center, Gainesville, Georgia, United States

Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States

Center for Cancer and Blood Disorders, Bethesda, Maryland, United States

St. Louis Cancer Care, Chesterfield, Missouri, United States

Oncology Hematology Care, Cincinnati, Ohio, United States

Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States

Chattanooga Oncology Hematology Associates, Chattanooga, Tennessee, United States

Tennessee Oncology, Nashville, Tennessee, United States

Contact Details

Name: David R Spigel, M.D.

Affiliation: SCRI Development Innovations, LLC

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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