Spots Global Cancer Trial Database for STUDY 15 - Comparing Gemcitabine/Carboplatin and Hydroxychloroquine Versus Carboplatin/Etoposide Therapy Alone in Small Cell Lung Cancer (SCLC)
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Trial Identification
Brief Title: STUDY 15 - Comparing Gemcitabine/Carboplatin and Hydroxychloroquine Versus Carboplatin/Etoposide Therapy Alone in Small Cell Lung Cancer (SCLC)
Official Title: A Phase II, Multicentre, Randomised Trial Comparing Combination Gemcitabine/Carboplatin and Hydroxychloroquine Versus Carboplatin/Etoposide Therapy Alone in Small Cell Lung Cancer (SCLC)
Study ID: NCT02722369
Conditions
Study Description
Brief Summary: To determine whether the combination of gemcitabine/carboplatin with hydroxychloroquine (HCQ) is associated with an improved clinical outcome (progression free and overall survival) compared with chemotherapy alone in patients with small cell lung cancer (SCLC)
Detailed Description: This is a multicentre, randomised, phase II trial which aims to compare the combination of hydroxychloroquine and gemcitabine/carboplatin versus standard carboplatin/etoposide chemotherapy, as first line treat in patients with stage IV disease. The standard first line chemotherapy treatment remains a platinum-based chemotherapy and this has been unchanged for 20 years. Novel active treatment approaches are urgently needed to improve survival in SCLC. Patients are randomised to one of two treatment arms; carboplatin/etoposide or gemcitabine/carboplatin/hydroxychloroquine.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Dorset County Hospital NHS Foundation Trust, Dorchester, , United Kingdom
Royal Surrey County Hospital, Guildford, , United Kingdom
The Princess Alexandra Hospital NHS Trust, Harlow, , United Kingdom
University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, , United Kingdom
University Hospital Leicester NHS Trust, Leicester, , United Kingdom
Guy's and St Thomas' Hospitals NHS Foundation Trust, London, , United Kingdom
UCLH, London, , United Kingdom
The Christie, Manchester, , United Kingdom
East and North Herts NHS Foundation Trust, Northwood, , United Kingdom
Nottingham University Hospitals NHS Trust, Nottingham, , United Kingdom
North West Anglia NHS Trust, Peterborough, , United Kingdom
Betsi Cadwaladr University Health Board, Rhyl, , United Kingdom
Airedale NHS Foundation Trust, Steeton, , United Kingdom
Contact Details
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