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Brief Title: Study of Amrubicin With or Without Cisplatin Versus Etoposide-cisplatin for Extensive Stage Small Cell Lung Cancer
Official Title: Randomized Phase II Study of Amrubicin as Single Agent or in Combination With Cisplatin Versus Etoposide-cisplatin as First-line Treatment in Patients With Extensive Stage SCLC (ES)
Study ID: NCT00388960
Brief Summary: The purpose of the study is to document the activity and safety of single agent amrubicin, amrubicin combined with cisplatin, and etoposide combined with cisplatin as first-line treatment in extensive disease small cell lung cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Algemeen Ziekenhuis Middelheim, Antwerpen, , Belgium
Universitair Ziekenhuis Antwerpen, Edegem, , Belgium
Universiteit Gent, Gent, , Belgium
U.Z. Gasthuisberg, Leuven, , Belgium
Domaine Universitaire du Sart-Tilman, Liege, , Belgium
Centre Hospitalier Regional de la Citadelle, Liege, , Belgium
Clinique Sainte Elisabeth, Namur, , Belgium
Instituto Nazionale per la Ricerca sul Cancro, Genova, , Italy
Universita Degli Studi Di Udine, Udine, , Italy
Academisch Medisch Centrum, Amsterdam, , Netherlands
The Netherlands Cancer Institute Antoni Van Leeuwenhoekziekenhuis, Amsterdam, , Netherlands
Medisch Spectrum Twente - Dept of Pulmonary Diseases, Enschede, , Netherlands
Leiden University Medical Centre, Leiden, , Netherlands
Academisch Ziekenhuis Maastricht, Maastricht, , Netherlands
Isala Kliniek, Zwolle, , Netherlands
Medical University of Gdansk - Dept Radiotherapy, Gdansk, , Poland
Clatterbridge Centre for Oncology NHS Trust, Bebington, Merseyside, United Kingdom
University of Dundee - Ninewells Hospital, Dundee, Scotland, United Kingdom
Belfast City Hospital, Belfast, , United Kingdom
Western General Hospital, Edinburgh, , United Kingdom
Princess Royal Hospital, Hull, , United Kingdom
Royal Marsden Hospital, London, London, , United Kingdom
Christie Hospital, Manchester, , United Kingdom
Sir Bobby Robson Cancer Trials Research Centre, Newcastle-Upon-Tyne, , United Kingdom
Royal Marsden Hospital Lung Unit, Sutton, , United Kingdom
Name: Mary O'Brien, MD
Affiliation: Royal Marsden Hospital, London, UK
Role: PRINCIPAL_INVESTIGATOR