Spots Global Cancer Trial Database for Phase II Trial of RAD001 (Everolimus) in Previously Treated Small Cell Lung Cancer
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Trial Identification
Brief Title: Phase II Trial of RAD001 (Everolimus) in Previously Treated Small Cell Lung Cancer
Official Title: Phase II Trial of RAD001 (Everolimus) in Previously Treated Small Cell Lung Cancer
Study ID: NCT00374140
Conditions
Interventions
Study Description
Brief Summary: This is a phase II, two-stage, open-label, single-agent study of the experimental drug RAD001 (everolimus) in patients with previously treated small cell lung cancer. RAD001 will be administered orally at a dose of 10 mg daily.
Detailed Description: This is a phase II, two-stage, open-label, single-agent study of the experimental drug RAD001 (everolimus) in patients with previously treated small cell lung cancer. Patients may have received up to 2 prior chemotherapy regimens for small cell lung carcinoma, but no prior therapy with an m-TOR inhibitor. RAD001 will be administered orally at a dose of 10 mg daily. A cycle will be defined as 3 weeks of study drug administration, and patients will have tumor measurements every 2 cycles. Study participation will continue until disease progression or intolerable toxicities. In addition, in patients who consent, archival tumor tissue (paraffin block from original biopsy) will be collected for research purposes.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
UPMC Cancer Center - Teramana Cancer Center - Steubenville, Steubenville, Ohio, United States
UPMC Cancer Center - Beaver, Beaver, Pennsylvania, United States
UPMC Cancer Center - Clairton, Clairton, Pennsylvania, United States
UPMC Cancer Center - Arnold Palmer Pavilion - Greensburg, Greensburg, Pennsylvania, United States
UPMC Cancer Center - Oakbrook Commons - Greensburg, Greensburg, Pennsylvania, United States
UPMC Cancer Center - Indiana, Indiana, Pennsylvania, United States
UPMC Cancer Center - John P. Murtha Pavilion - Johnstown, Johnstown, Pennsylvania, United States
UPMC Cancer Center - McKeesport, McKeesport, Pennsylvania, United States
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania, United States
UPMC Cancer Center - Sewickley Medical Oncology/Hematology Group, Moon, Pennsylvania, United States
UPMC Cancer Center - New Castle, New Castle, Pennsylvania, United States
UPMC Cancer Center - St. Margaret's, Pittsburgh, Pennsylvania, United States
UPMC Cancer Center - Mercy, Pittsburgh, Pennsylvania, United States
University of Pittsburgh Cancer Institute - Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
UPMC Cancer Center - Passavant, Pittsburgh, Pennsylvania, United States
UPMC Cancer Center - Upper St. Clair, Pittsburgh, Pennsylvania, United States
UPMC Cancer Center - Uniontown, Uniontown, Pennsylvania, United States
UPMC Cancer Center - Washington, Washington, Pennsylvania, United States
UPMC Cancer Center - North Hills, Wexford, Pennsylvania, United States
Contact Details
Name: Ahmad Tarhini, MD, PhD
Affiliation: University of Pittsburgh
Role: PRINCIPAL_INVESTIGATOR
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