The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: DAREONᵀᴹ-8: A Study to Test How Well Different Doses of BI 764532 in Addition to Standard of Care Are Tolerated by People With Advanced Small Cell Lung Cancer
Official Title: DAREONᵀᴹ-8: A Phase I, Open-label, Dose Escalation and Expansion Trial of Repeated Intravenous Infusions of BI 764532 Combined With Standard of Care (Platinium, Etoposide, and Anti-PD-L1) in Patients With Extensive-stage Small Cell Lung Carcinoma
Study ID: NCT06077500
Brief Summary: This study is open to adults with extensive stage small cell lung cancer. The study is in people with advanced cancer that are eligible for standard of care including chemotherapy and anti-PD-L1 (Programmed Cell Death Ligand 1) immunotherapy. The purpose of this study is to find out the highest dose of BI 764532 that people can tolerate when taken together with standard of care. BI 764532 is an antibody-like molecule that may help the immune system fight cancer. Participants get BI 764532 and different standard treatments as infusions into a vein. If there is benefit for the participants and if they can tolerate it, the treatment is given for the entire duration of the study. During this time, participants visit the study site regularly. The visits also depend on the response to the treatment. At the study visits, the doctors check the health of the participants, take necessary laboratory tests, and note any health problems that could have been caused by the study treatment.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Brussels - UNIV Saint-Luc, Bruxelles, , Belgium
Kortrijk - HOSP AZ Groeninge Kennedylaan, Kortrijk, , Belgium
INS Bergonie, Bordeaux, , France
HOP Louis Pradel, Bron, , France
HOP Civil, Strasbourg, , France
INS Gustave Roussy, Villejuif, , France
Universitätsklinikum Gießen und Marburg GmbH, Gießen, , Germany
National Cancer Center Hospital, Tokyo, Chuo-ku, , Japan
Japanese Foundation for Cancer Research, Tokyo, Koto-ku, , Japan
Medical University Gdansk, Gdansk, , Poland
Polish Mother's Memorial Hospital - Research Institute, Lodz, , Poland
MED POLONIA SP Z O O, Clinical Trials Department,Poznan, Poznan, , Poland
Hospital Ramón y Cajal, Madrid, , Spain
Hospital Virgen Macarena, Sevilla, , Spain
Instituto Valenciano de Oncología, Valencia, , Spain