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Spots Global Cancer Trial Database for Observation Versus Post-surgery Radiotherapy After Complete Exeresis in Soft Tissues Members Sarcoma

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Trial Identification

Brief Title: Observation Versus Post-surgery Radiotherapy After Complete Exeresis in Soft Tissues Members Sarcoma

Official Title: Randomised Multicentric Phase III Study Comparing Observation Versus Post-surgery Radiotherapy After Complete Exeresis With Margins Greater Than or Equal to 1 cm in Soft Tissues Members Sarcoma.

Study ID: NCT00870701

Study Description

Brief Summary: Soft tissue sarcomas represent less than 1% of malignant tumors in adults and sarcomas members represent 60% of them. These rare tumors involve complex multidisciplinary care better in centers having expertise. Loco-regional therapy strategies have evaluated over time for tumors of members leading to propose more often the combination of a large conservative tumor excision with radiotherapy. Results have been demonstrated equivalent to those of an amputation in terms of local control and survival. The local recurrence rate for sarcomas of the members of any kind after surgery with or without radiotherapy in the literature varies from 10 to 30%. The main objective is to achieve a low recurrence rate while maintaining the function. The question remains the possibility of an absence of irradiation in selected cases in a de-escalation therapy order.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Institut de Cancérologie de l'Ouest - Centre Paul Papin, Angers, , France

Institut Bergonié, Bordeaux, , France

Centre François Baclesse, Caen, , France

Centre Jean Perrin, Clermont Ferrand, , France

Hopital Mondor, Créteil, , France

Centre Oscar Lambret, Lille, , France

Centre Léon Bérard, Lyon, , France

Institut Paoli Calmette, Marseille, , France

CHU de la Timone, Marseille, , France

Institut du Cancer de Montpellier - Val d'Aurelle, Montpellier, , France

Centre Alexis Vautrin, Nancy, , France

Centre Antoine Lacassagne, Nice, , France

Centre Henri Becquerel, Rouen, , France

Institut de Cancérologie de l'Ouest - Centre René Gauducheau, Saint Herblain (Nantes), , France

Institut de Cancerologie de La Loire, Saint-Priest en Jarez, , France

Centre Paul Strauss, Strasbourg, , France

Institut Claudius Regaud, Toulouse, , France

Institut Gustave Roussy, Villejuif, , France

Contact Details

Name: Martine DELANNES, MD

Affiliation: Institut Claudius Regaud

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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