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Brief Title: Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma
Official Title: A Phase 2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3β) Inhibitor, Combined With Chemotherapy in Advanced Soft Tissue and Bone Sarcomas
Study ID: NCT05116800
Brief Summary: This is an open label, two-stratum, phase 2 clinical trial evaluating the efficacy of 9-ING-41 in combination with gemcitabine/docetaxel in patients ≥10 years of age with advanced sarcoma. 9-ING-41 in combination with gemcitabine and docetaxel will lead to sustained disease control and/or increase the rates of objective response in patients with unresectable or metastatic soft tissue and bone sarcomas.
Detailed Description:
Minimum Age: 10 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hasbro Children's Hospital, Providence, Rhode Island, United States
Lifespan Cancer Insitute, Providence, Rhode Island, United States
Name: Bradley D DeNardo, MD
Affiliation: Brown University
Role: PRINCIPAL_INVESTIGATOR
Name: Galina G Lagos, MD
Affiliation: Lifespan Cancer Institute
Role: PRINCIPAL_INVESTIGATOR