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Brief Title: A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors
Official Title: A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors
Study ID: NCT02223247
Brief Summary: This first in human phase 1 study of TVB-2640 is being conducted in patients with advanced stage solid malignant tumors. This research is being done to find out how safe and useful TVB-2640 is for patients who have received previous cancer therapy, and for whom no therapy exists that would be curative or might provide significant benefit. TVB-2640 belongs to a class of drugs called fatty acid synthase inhibitors (FASN inhibitors). This means that they interfere with the body's (and the tumor's) ability to use a substance called fatty acid synthase (FASN). Research has shown that some tumors appear to need FASN to keep growing.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
, Scottsdale, Arizona, United States
, Denver, Colorado, United States
, Sarasota, Florida, United States
, Oklahoma City, Oklahoma, United States
, Nashville, Tennessee, United States
, Dallas, Texas, United States
, San Antonio, Texas, United States
, Charthouse Square, London, , United Kingdom
, London, , United Kingdom
, Manchester, , United Kingdom
, West Smithfield, London, , United Kingdom
Name: Jeffrey R Infante, MD
Affiliation: The Sarah Cannon Research Institute
Role: PRINCIPAL_INVESTIGATOR