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Spots Global Cancer Trial Database for A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors

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Trial Identification

Brief Title: A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors

Official Title: A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors

Study ID: NCT02223247

Interventions

TVB-2640

Study Description

Brief Summary: This first in human phase 1 study of TVB-2640 is being conducted in patients with advanced stage solid malignant tumors. This research is being done to find out how safe and useful TVB-2640 is for patients who have received previous cancer therapy, and for whom no therapy exists that would be curative or might provide significant benefit. TVB-2640 belongs to a class of drugs called fatty acid synthase inhibitors (FASN inhibitors). This means that they interfere with the body's (and the tumor's) ability to use a substance called fatty acid synthase (FASN). Research has shown that some tumors appear to need FASN to keep growing.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

, Scottsdale, Arizona, United States

, Denver, Colorado, United States

, Sarasota, Florida, United States

, Oklahoma City, Oklahoma, United States

, Nashville, Tennessee, United States

, Dallas, Texas, United States

, San Antonio, Texas, United States

, Charthouse Square, London, , United Kingdom

, London, , United Kingdom

, Manchester, , United Kingdom

, West Smithfield, London, , United Kingdom

Contact Details

Name: Jeffrey R Infante, MD

Affiliation: The Sarah Cannon Research Institute

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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