Spots Global Cancer Trial Database for A Study of BGB-24714 as Monotherapy and With Combination Therapies in Participants With Solid Tumors
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Trial Identification
Brief Title: A Study of BGB-24714 as Monotherapy and With Combination Therapies in Participants With Solid Tumors
Official Title: A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of Second Mitochondrial-derived Activator of Caspases Mimetic BGB-24714 as Monotherapy and With Combination Therapies in Patients With Solid Tumors
Study ID: NCT05381909
Conditions
Study Description
Brief Summary: This study aims to understand how safe and well-tolerated a drug called BGB-24714 is when used alone, or in combination with chemotherapy or radiation therapy, for people with advanced or spreading solid tumors. The main objective is to identify the highest tolerable dose or the highest administered dose of BGB-24714. Additionally, the study aims to identify the most suitable doses for further investigation in larger groups of participants.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Banner Md Anderson Cancer Center, Gilbert, Arizona, United States
Florida Cancer Specialist (Scri) Sarasota, Sarasota, Florida, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Upmc Hillman Cancer Center(Univ of Pittsburgh), Pittsburgh, Pennsylvania, United States
Tennessee Oncology, Pllc Nashville, Nashville, Tennessee, United States
The University of Texas Md Anderson Cancer Center (Department Gi Medical Oncology), Houston, Texas, United States
University of Washington, Seattle, Washington, United States
Princess Alexandra Hospital, Brisbane, Queensland, Australia
Icon Cancer Care South Brisbane, South Brisbane, Queensland, Australia
Austin Health, Heidelberg, Victoria, Australia
Chongqing Cancer Hospital, Chongqing, Chongqing, China
Henan Cancer Hospital, Zhengzhou, Henan, China
Hunan Cancer Hospital, Changsha, Hunan, China
Shandong Provincial Hospital, Jinan, Shandong, China
Shandong Cancer Hospital, Jinan, Shandong, China
National Cancer Center, Goyangsi, Gyeonggido, Korea, Republic of
Seoul National University Bundang Hospital, Seongnamsi, Gyeonggido, Korea, Republic of
The Catholic University of Korea, St Vincents Hospital, Suwonsi, Gyeonggido, Korea, Republic of
Gachon University Gil Medical Center, Incheon, Incheon Gwang'yeogsi, Korea, Republic of
Severance Hospital Yonsei University Health System, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Auckland City Hospital, Auckland, , New Zealand
Contact Details
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