Spots Global Cancer Trial Database for A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors
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Trial Identification
Brief Title: A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors
Official Title: A Phase I/II Trial of AK112 in Advanced Solid Tumor
Study ID: NCT04597541
Conditions
Interventions
Study Description
Brief Summary: This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of AK112, a PD-1/VEGF bispecific antibody, as a single agent in adult subjects with advanced solid tumor malignancies. This trial is a two parts, phase I/II study. All patients are advanced solid tumor, Eastern Cooperative Oncology Group (ECOG) performance status 0-1. Part one is dose escalation phase,part two is dose expansion phase. The primary end point is safety. Secondary end points are objective response rate,progression-free survival and overall survival per RECIST1.1.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Contact Details
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