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Brief Title: PD-1 Antibody Expressing CAR T Cells for Mesothelin Positive Advanced Malignancies
Official Title: PD-1 Antibody Expressing Chimeric Antigen Receptor T Cells for Mesothelin Positive Advanced Malignancies
Study ID: NCT03030001
Brief Summary: This is a single-arm, open-label, one center, dose escalation clinical study, to determine the safety and efficacy of infusion of autologous T cells engineered to express immune checkpoint antibody and chimeric antigen receptor targeting mesothelin in adult patients with mesothelin positive, recurrent or refractory malignant tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Ningbo No.5 Hospital (Ningbo Cancer Hospital), Ningbo, Zhejiang, China
Name: Qijun Qian, PhD
Affiliation: Shanghai Cell Therapy Engineering Research Institute
Role: STUDY_CHAIR