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Spots Global Cancer Trial Database for Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)

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Trial Identification

Brief Title: Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)

Official Title: A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)

Study ID: NCT03822117

Interventions

Pemigatinib

Study Description

Brief Summary: The purpose of this study is to evaluate the efficacy and safety of pemigatinib in participants with previously treated locally advanced/metastatic or surgically unresectable solid tumor malignancies harboring activating FGFR mutations or translocations.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Cancer Treatment Centers of America, Goodyear, Arizona, United States

Mayo Clinic Hospital, Phoenix, Arizona, United States

The University of Arizona Cancer Center, Tucson, Arizona, United States

Chao Family Comprehensive Cancer Center University of California, Irvine, Orange, California, United States

Stanford Cancer Center, Palo Alto, California, United States

John Wayne Cancer Institute, Santa Monica, California, United States

St. Joseph Heritage Healthcare, Santa Rosa, California, United States

Florida Cancer Specialists & Research Institute, Fort Myers, Florida, United States

Mayo Clinic Jacksonville, Jacksonville, Florida, United States

Florida Cancer Specialists, Saint Petersburg, Florida, United States

Florida Cancer Specialists, Tallahassee, Florida, United States

Florida Cancer Specialists, West Palm Beach, Florida, United States

Illinois Cancer Specialists, Arlington Heights, Illinois, United States

Edward H Kaplan & Associates, Skokie, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Cancer Treatment Centers of America, Zion, Illinois, United States

Indiana University Health - Arnett Cancer Care, Lafayette, Indiana, United States

University of Iowa, Iowa City, Iowa, United States

University of Kansas Cancer Center, Westwood, Kansas, United States

Ochsner Clinic, New Orleans, Louisiana, United States

Central Maine Medical Center, Lewiston, Maine, United States

Massachusetts General Hospital, Boston, Massachusetts, United States

Umass Memorial Medical Center, Inc., Worcester, Massachusetts, United States

Mayo Clinic Rochester, Rochester, Minnesota, United States

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Summit Medical Group, Florham Park, New Jersey, United States

Winthrop University Hospital, Mineola, New York, United States

Oncology Specialists of Charlotte, Charlotte, North Carolina, United States

Duke Cancer Center, Durham, North Carolina, United States

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States

Stephenson Cancer Center, Oklahoma City, Oklahoma, United States

Southwestern Regional Medical Center, Tulsa, Oklahoma, United States

Cancer Institute of Greenville Health System, Greenville, South Carolina, United States

The West Clinic Pc, Germantown, Tennessee, United States

University of Texas Southwestern Medical Center, Dallas, Texas, United States

Houston Methodist Hospital, Houston, Texas, United States

Joe Arrington Cancer Center, Lubbock, Texas, United States

Virginia Cancer Specialists, Pc, Fairfax, Virginia, United States

Virginia Oncology Associates-Lake Wright, Norfolk, Virginia, United States

Seattle Cancer Care Alliance, Seattle, Washington, United States

Multicare Institute For Research & Innovation, Tacoma, Washington, United States

West Virginia University Hospitals Inc, Morgantown, West Virginia, United States

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States

The Finsen Centre National Hospital, Copenhagen, , Denmark

Institut Bergonie, Bordeaux, , France

CENTRE GEORGES FRAN�OIS LECLERC, Dijon Cedex, , France

Centre Antoine Lacassagne, Nice, , France

Hospital Saint Louis, Paris, , France

A.P.H. Paris Hopital Cochin, Paris, , France

Institut Universitaire Du Cancer de Toulouse Oncopole, Toulouse, , France

University Medical Center Freiburg, Freiburg, , Germany

University Medical Centre Hamburg-Eppendorf, Centre of Oncology, Hamburg, , Germany

Universitatsklinikum Koln, Koln, , Germany

University Hospital Grosshadern Munich, Munich, , Germany

Universitaetsklinikum in Tubingen, Tubingen, , Germany

Ha Emek Medical Center, Afula, , Israel

Rambam Health Care Campus, Haifa, , Israel

Hadassah Hebrew University Medical Center Ein Karem Hadassah, Jerusalem, , Israel

Rabin Medical Center - Beilinson Hospital, Petach Tikva, , Israel

Assaf Harofeh Medical Center, Zerifin, , Israel

L AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA POLICLINICO S. ORSOLA � MALPIGHI, Bologna, , Italy

Fondazione Del Piemonte Per L Oncologia Ircc Candiolo, Candiolo, , Italy

Fondazione Irccs Istituto Nazionale Dei Tumori, Milan, , Italy

Istituto Nazionale Tumori Irccs Fondazione Pascale, Napoli, , Italy

Istituto Nazionale Tumori Regina Elena Irccs, Roma, , Italy

Centro Ricerche Cliniche Di Verona (Crc), Verona, , Italy

National Hospital Organization Kyushu Cancer Center, Fukuoka, , Japan

Kanazawa University Hospital, Ishikawa, , Japan

Kobe University Hospital, Kobe, , Japan

Tohoku University Hospital, Sendai-shi, , Japan

Keio University Hospital, Shinjuku-ku, , Japan

Shizuoka Cancer Center, Shizuoka, , Japan

Kanagawa Cancer Center, Yokohama-shi, , Japan

National Cancer Center, Goyang-si, , Korea, Republic of

Seoul National University Bundang Hospital, Seongnam-si, , Korea, Republic of

Severance Hospital Yonsei University Health System, Seoul, , Korea, Republic of

Samsung Medical Center, Seoul, , Korea, Republic of

Hospital General Universitario Vall D Hebron, Barcelona, , Spain

Hospital Clinic I Provincial, Barcelona, , Spain

Centro Integral Oncologico Clara Campal (Ciocc), Madrid, , Spain

Hospital Regional Universitario de Malaga, Malaga, , Spain

Clinica Universidad de Navarra (Cun), Pamplona, , Spain

Hospital Universitario Marques de Valdecilla, Santander, , Spain

Hospital Universitario Y Politcnico de La Fe, Valencia, , Spain

Inselspital - Universitaetsspital Bern, Bern, , Switzerland

Universitatsspital Zurich, Zuerich, , Switzerland

University College London Hospitals (Uclh), London, , United Kingdom

Imperial College Healthcare Nhs Trust - Hammersmith Hospital, London, , United Kingdom

Sarah Cannon Research Institute, London, , United Kingdom

Contact Details

Name: Peter Langmuir, MD

Affiliation: Incyte Corporation

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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