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Spots Global Cancer Trial Database for Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients

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Trial Identification

Brief Title: Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients

Official Title: Association of Genetic Polymorphisms With Capecitabine-based Chemotherapy Toxicities in Chinese Solid Tumor Patients

Study ID: NCT03258099

Study Description

Brief Summary: Capecitabine is one of the most active agents in the treatment of many kinds of solid tumors. However, variability in toxicity and response remains a major problem for patients receiving capecitabine. It is general that there are many factors for individual differences of drugs in clinical application, of which genetic factors accounted for more than 20%. Toxicities of capecitabine, such as diarrhea, hand-foot syndrome or anemia, were evaluated for possible relationship with pharmacogenetic polymorphisms in several pharmacogenomics studies. Due to the levels of evidence of those studies are low and lack of sufficient research data of Chinese, it has the important significance in studying individual differences of capecitabine in toxicities, through the pharmacogenomics research. The aim of this study is to evaluating the association genetic polymorphisms with capecitabine-based chemotherapy toxicities in chinese solid tumor patients. By detecting the gene polymorphism, investigators intend to study the pharmacokinetic/pharmacogenomics (PK-PG) correlation of capecitabine and provide scientific basis for precise medication guide for people to use capecitabine.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Peking University First Hospital, Beijing, Beijing, China

Affiliated Hospital of Academy of Military Medical Sciences, Beijing, Beijing, China

Fuling Center Hospital of Chongqing City, Chongqing, Chongqing, China

Henan Cancer Hospital, Zhengzhou, Henan, China

The First Hospital of China Medical University, Shenyang, Liaoning, China

Yantai Yuhuangding Hospital, Yantai, Shandong, China

Yunnan Cancer Hospital, Kunming, Yunnan, China

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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