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Brief Title: A Study of the Safety and Efficacy of Atezolizumab Administered in Combination With Bevacizumab and/or Other Treatments in Participants With Solid Tumors
Official Title: An Open-Label, Multicenter Phase Ib Study of The Safety and Efficacy of Atezolizumab (Anti-PD-L1 Antibody) Administered in Combination With Bevacizumab and/or Other Treatments in Patients With Solid Tumors
Study ID: NCT02715531
Brief Summary: This study will evaluate the safety, efficacy, and pharmacokinetics of atezolizumab in combination with bevacizumab, bevacizumab + oxaliplatin, leucovorin and 5-fluorouracil (5-FU) (FOLFOX), vanucizumab, nab-paclitaxel + gemcitabine, FOLFOX, or 5-FU + cisplatin, in participants with solid tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Stanford Cancer Institute; Hematology, Palo Alto, California, United States
University of Colorado Hospital, Aurora, Colorado, United States
Yale School of Medicine, New Haven, Connecticut, United States
Georgetown University Medical Center, Washington, District of Columbia, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Mayo Clinic, Rochester, Minnesota, United States
Columbia University Medical Center, New York, New York, United States
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States
Duke Cancer Institute, Durham, North Carolina, United States
Sarah Cannon Research Inst., Nashville, Tennessee, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Monash Medical Centre Clayton, Clayton, Victoria, Australia
Austin Hospital, Heidelberg, Victoria, Australia
The 81st Hospital of P.L.A., Nanjing City, , China
National Cancer Center Hospital East, Chiba, , Japan
Yokohama City University Medical Center, Kanagawa, , Japan
Kanagawa Cancer Center, Kanagawa, , Japan
The Cancer Institute Hospital of JFCR, Tokyo, , Japan
Seoul National University Bundang Hospital, Seongnam-si, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Auckland City Hospital, Auckland, , New Zealand
China Medical University Hospital, North Dist., , Taiwan
National Cheng Kung University Hospital, Tainan, , Taiwan
Taipei Veterans General Hospital, Taipei City, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Chang Gung Medical Foundation - LINKOU; Dept of Cardiology, Taoyuan County, , Taiwan
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR