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Brief Title: A PhaseI Study of HL-085 Plus Vemurafenib in Solid Tumor With BRAF V600 Mutation
Official Title: A Phase I, Single Arm, Dose Escalation Study to Evaluate Safety, Pharmacokinetics and Preliminary Efficacy of HL-085 Plus Vemurafenib in Patients With BRAF V600 Mutant Advanced Solid Tumor
Study ID: NCT03781219
Brief Summary: This is a phase I, open-label, dose escalation study to evaluate tolerability, safety, pharmacokinetics and efficacy in patients with BRAF V600 mutant advanced solid tumor by HL-085 plus Vemurafenib treatment.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Cancer Hospital Chinese Academy of Medical Science, Beijing, Beijing, China
Beijing Oncology Hospital, Beijing, Beijing, China
Henan Province Oncology Hospital, Zhengzhou, Henan, China
First Affiliated Hospital, Medicine School of Zhejiang University, Hangzhou, Zhejiang, China
Name: Hongqi Tian, Ph.D
Affiliation: Shanghai Kechow Pharma, Inc.
Role: STUDY_DIRECTOR