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Brief Title: Basket Trial in Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3- (FUZE Clinical Trial)
Official Title: A Phase II Basket Study of the Oral Selective Pan-FGFR Inhibitor Debio 1347 in Subjects With Solid Tumors Harboring a Fusion of FGFR1, FGFR2 or FGFR3
Study ID: NCT03834220
Brief Summary: The primary objective of this study is to assess the efficacy of Debio 1347 in terms of objective response rate (ORR) in participants with solid tumors harboring fibroblast growth factor receptor (FGFR)1-3 gene fusion/rearrangement.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Ironwood Cancer & Research Centers - Scottsdale, Scottsdale, Arizona, United States
University of Arizona Cancer Center, Tucson, Arizona, United States
Moores UCSD Cancer Center, La Jolla, California, United States
University of California San Francisco, San Francisco, California, United States
Sarcoma Oncology Center, Santa Monica, California, United States
H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa, Florida, United States
James Graham Brown Cancer Center, Louisville, Kentucky, United States
Tulane University Cancer Center, New Orleans, Louisiana, United States
The John Hopkins Hospital, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan, Ann Arbor, Michigan, United States
Memorial Sloan Kettering Cancer Center, Middletown, New Jersey, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Memorial Sloan Kettering Cancer Center, Harrison, New York, United States
Memorial Sloan-Kettering Hospital, New York, New York, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
UC Health, LLC., Cincinnati, Ohio, United States
The Ohio State University Wexner Medical Center - James Cancer Hospital, Columbus, Ohio, United States
CTCA Cancer Treatment Centers, Tulsa, Oklahoma, United States
West Penn - Allegheny Oncology Network, Pittsburgh, Pennsylvania, United States
MD Anderson Cancer Center, Houston, Texas, United States
University of Utah Hospitals & Clinics, Salt Lake City, Utah, United States
Fred Hutchinson/Seattle Care Alliance, Seattle, Washington, United States
University of Wisconsin, Madison, Wisconsin, United States
Southern Highlands Private Hospital, Bowral, , Australia
Peninsula and Southeast Oncology (PASO), Frankston, , Australia
Linear Clinical Research, B Block Sir Charles Gairdner Hospital, Nedlands, , Australia
John Flynn Private Hospital, Tugun, , Australia
LKH - Universitätsklinikum der PMU Salzburg, Salzburg, , Austria
Landesklinikum Wiener Neustadt, Wiener Neustadt, , Austria
Hospital de Caridade de Ijuí, Avenida David J Martins, Ijuí, , Brazil
Hospital de Clínicas de Porto Alegre, Rio Grande, , Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André, , Brazil
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, Avenida Doutor Arnaldo, São Paulo, , Brazil
MHAT - Dobrich, Dobrich, , Bulgaria
Complex Oncological Center - Plovdiv, EOOD, Plovdiv, , Bulgaria
MHAT "Serdika", EOOD, Sofia, , Bulgaria
General Hospital Varazdin, Varaždin, , Croatia
University Hospital Centre, Sestre Milosrdnice, Zagreb, , Croatia
Fakultni nemocnice u sv. Anny v Brne, Brno, , Czechia
Fakultni nemocnice Hradec Kralove, Hradec Králové, , Czechia
Fakultni nemocnice Olomouc, Olomouc, , Czechia
Thomayerova nemocnice, Prague, , Czechia
Fakultni nemocnice Kralovske Vinohrady, Praha, , Czechia
Ålborg Universitets Hospital, Aalborg, , Denmark
Herlev Hospital, Herlev, , Denmark
Odense Universitetshospital, Odense, , Denmark
Docrates Syöpäsairaala, Helsinki, , Finland
Helsinki University Hospital, Helsinki, , Finland
ICO - Site Paul Papin, Angers, , France
CHU Bordeaux - Hôpital Saint André, Groupe Hospitalier Sud - Hôpital Haut-Lévêque, Bordeaux, , France
Centre Oscar Lambret, Lille, , France
Groupe Hospitalier Sud - Hôpital Haut Lévêque, Pessac, , France
ICO - Site René Gauducheau, Saint-Herblain, , France
Institut Gustave Roussy, Villejuif, , France
General Hospital of Athens Laiko, Athens, , Greece
General Hospital of Athens of Chest Diseases "SOTIRIA", Athens, , Greece
General Hospital of Athens "Alexandra", Athens, , Greece
University General Hospital of Ioannina, Ioánnina, , Greece
Seoul National University Bundang Hospital, Department of Oncology Medical office, Gyeonggi-do, , Korea, Republic of
The Catholic University of Korea, St. Vincent's Hospital, CRC Room, 3F, Gyeonggi-do, , Korea, Republic of
Gachon University Gil Medical Center, CRC Room, 18F, Artificial intelligence hospital, Incheon, , Korea, Republic of
Korea University Anam Hospital, Seoul, , Korea, Republic of
Seoul National University Hospital (SNUH), Seoul, , Korea, Republic of
Ajou University Hospital, CRC room, Clinical Trial Center, Suwon, , Korea, Republic of
VU Medisch Centrum, Amsterdam, , Netherlands
Haga Ziekenhuis, Den Haag, , Netherlands
Akershus University Hospital, Lørenskog, , Norway
Radiumhospitalet, Montebello, Oslo, , Norway
Cebu Doctors' University Hospital (CDUH), Research Office, Cebu City, , Philippines
Philippine General Hospital, Clinical Trial Unit Room 5, Medical Research Laboratory, Ermita, , Philippines
St. Luke's Medical Center, Human Cancer Biobank Research Center, Quezon City, , Philippines
Szpital Kliniczny im.Heliodora Swiecickiego Uniwersytetu Medycznego im.K. Marcinkowskiego w Poznaniu, Poznań, , Poland
MTZ Clinical Research, Warszawa, , Poland
Centrum Onkologii-Instytut im.M.Sklodowskiej Curie, Warszawa, , Poland
S.C Delta Health Care S.R.L, Bucuresti, , Romania
S.C Medisprof S.R.L., Cluj-Napoca, , Romania
S.C Centrul de Oncologie Sf. Nectarie S.R.L., Craiova, , Romania
S.C Oncocenter Oncologie Clinica S.R.L., Timişoara, , Romania
SBIH of Arkhangelsk region "Arkhangelsk Clinical Oncological Dispensary", Arkhangel'sk, , Russian Federation
TSBHI "Altai Territorial oncological dispensary", Barnaul, , Russian Federation
LLC Evimed, Chelyabinsk, , Russian Federation
FSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow, , Russian Federation
BHI of Omsk region "Clinical Oncology Dispensary", Omsk, , Russian Federation
Tomsk Research Instutite of Oncology, Tomsk, , Russian Federation
Singapore National Cancer Center (SNCC), Singapore, , Singapore
Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, , Singapore
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Centro Integral Oncologico Clara Campal, Madrid, , Spain
Hospital Clinico Universitario de Valencia, Valencia, , Spain
Shuang Ho Hospital, New Taipei City, , Taiwan
Taichung Veterans General Hospital, The Radiation Oncology Department, Taichung, , Taiwan
National Cheng Kung University Hospital, Tainan, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Taipei Medical University Hospital (TMUH), Taipei, , Taiwan
Taipei Veterans General Hospital, Medical Science & Technology Building, Taipei, , Taiwan
Linkou Chang-Gung Memorial Hospital, Taoyuan, , Taiwan
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU, Dnipro, , Ukraine
SI V.T. Zaycev Institute of general & urgent surgery of National academy medical sciences of Ukraine, Department of purulent surgery, Kharkiv, , Ukraine
Communal Non-profit Enterprise Regional Center of Oncology, Kharkiv, , Ukraine
Ninewells Hospital, Dundee, , United Kingdom
Guy's Hospital, London, , United Kingdom
Hammersmith Hospital, London, , United Kingdom
The Christie, Manchester, , United Kingdom