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Spots Global Cancer Trial Database for Safety Study of PLX108-01 in Patients With Solid Tumors

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Trial Identification

Brief Title: Safety Study of PLX108-01 in Patients With Solid Tumors

Official Title: A Phase 1 Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of PLX3397 in Patients With Advanced, Incurable, Solid Tumors in Which the Target Kinases Are Linked to Disease Pathophysiology

Study ID: NCT01004861

Conditions

Solid Tumor

Interventions

PLX3397

Study Description

Brief Summary: PLX3397 is a selective inhibitor of Fms, Kit, and oncogenic Flt3 activity. The primary objective of this study is to evaluate the safety and pharmacokinetics of orally administered PLX3397 in patients with advanced, incurable, solid tumors in which these target kinases are linked to disease pathophysiology. The secondary objective is to measure the pharmacodynamic activity of PLX3397 via blood, plasma and urine biomarkers of Fms activity.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

HonorHealth, Scottsdale, Arizona, United States

UCLA, Los Angeles, California, United States

Rocky Mountain Cancer Centers, Denver, Colorado, United States

Massachusetts General Hospital, Boston, Massachusetts, United States

Dana Farber Cancer Institute, Boston, Massachusetts, United States

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York, United States

Pennsylvania Oncology Hematology Associates, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Vanderbilt-Ingram Medical Center, Nashville, Tennessee, United States

Texas Oncology, PA (North), Dallas, Texas, United States

Virginia Oncology Associates, Norfolk, Virginia, United States

Evergreen Hematology & Oncology, Spokane, Washington, United States

Contact Details

Name: Medical Director

Affiliation: Daiichi Sankyo

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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