Spots Global Cancer Trial Database for PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas
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Trial Identification
Brief Title: PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas
Official Title: An Open-Label, Dose-Finding and Proof of Concept Study of the PD-L1 Probody™ Therapeutic , CX-072, as Monotherapy and in Combination With Yervoy (Ipilimumab) or With Zelboraf (Vemurafenib) in Subjects With Advanced or Recurrent Solid Tumors or Lymphomas
Study ID: NCT03013491
Study Description
Brief Summary: The purpose of this first-in-human study of CX-072 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-072 administered intravenously (IV) as a single agent or in combination with ipilimumab or vemurafenib in adult subjects with advanced or recurrent solid tumors or lymphomas. PROCLAIM-CX-072: PRObody CLinical Assessment In Man CX-072 clinical trial CX-072 is a Probody™ therapeutic directed against PD-L1 (programmed cell death ligand 1). Probody therapeutics are proteolytically-activatable antibodies (Abs) designed to widen the therapeutic index by minimizing drug interaction with normal tissue while retaining anti-tumor activity. Probody therapeutics are "masked" to attenuate binding to target in healthy tissue but can become "unmasked" in the tumor microenvironment by tumor-specific protease activity. PROBODY is a trademark of CytomX Therapeutics, Inc.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
PROCLAIM Investigative Site, Los Angeles, California, United States
PROCLAIM Investigative Site, Los Angeles, California, United States
PROCLAIM Investigative Site, New Haven, Connecticut, United States
PROCLAIM Investigative Site, Chicago, Illinois, United States
PROCLAIM Investigative Site, Indianapolis, Indiana, United States
PROCLAIM Investigative Site, Boston, Massachusetts, United States
PROCLAIM Investigative Site, Detroit, Michigan, United States
PROCLAIM Investigative Site, New York, New York, United States
PROCLAIM Investigative Site, New York, New York, United States
PROCLAIM Investigative Site, New York, New York, United States
PROCLAIM Investigative Site, Portland, Oregon, United States
PROCLAIM Investigative Site, Nashville, Tennessee, United States
PROCLAIM Investigative Site, Dallas, Texas, United States
PROCLAIM Investigative Site, Houston, Texas, United States
PROCLAIM Investigative Site, Fairfax, Virginia, United States
PROCLAIM Investigative Site, Madison, Wisconsin, United States
PROCLAIM Investigative Site, Amsterdam, , Netherlands
PROCLAIM Investigative Site, Groningen, , Netherlands
PROCLAIM Investigative Site, Rotterdam, , Netherlands
PROCLAIM Investigative Site, Katowice, , Poland
PROCLAIM Investigative Site, Pamplona, Navarre, Spain
PROCLAIM Investigative Site, Barcelona, , Spain
PROCLAIM Investigative Site, Barcelona, , Spain
PROCLAIM Investigative Site, Madrid, , Spain
PROCLAIM Investigative Site, Madrid, , Spain
PROCLAIM Investigative Ssite, Valencia, , Spain
PROCLAIM Investigative Site, Dnepropetrovsk, , Ukraine
PROCLAIM Invetigative Site, Glasgow, , United Kingdom
PROCLAIM Investigative Site, London, , United Kingdom
PROCLAIM Investigative Site, Manchester, , United Kingdom
PROCLAIM Investigative Site, Newcastle upon Tyne, , United Kingdom
Contact Details
Name: Lawrence Lu, M.D.
Affiliation: CytomX Therapeutics
Role: STUDY_DIRECTOR
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