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Brief Title: Safety Study of PEGPH20 Given to Patients With Advanced Solid Tumors
Official Title: Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacodynamic, and Pharmacokinetic Study of PEGPH20 (PEGylated Recombinant Human Hyaluronidase) Given Intravenously to Patients With Advanced Solid Tumors
Study ID: NCT00834704
Brief Summary: Open-label, multicenter, dose-escalation, safety, pharmacodynamic, and pharmacokinetic study.
Detailed Description: This is a study of PEGPH20 in human subjects and is designed to evaluate the safety of PEGPH20 and to determine the maximum tolerated dose of PEGPH20. All patients will receive PEGPH20. Each group of patients will receive a higher dose than the previous group. This will continue until the group with the highest planned dose completes the study or until a group has major side effects from their assigned dose.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
T Gen Clinical Research Services, Scottsdale, Arizona, United States
Premiere Oncology, Santa Monica, California, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Name: Joy Zhu, M.D.
Affiliation: Halozyme Therapeutics
Role: STUDY_DIRECTOR