Spots Global Cancer Trial Database for A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors
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Trial Identification
Brief Title: A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors
Official Title: A Study to Learn How Well the Drug Larotrectinib Works in Adults With Different Solid Cancers With a Change in the Genes Called NTRK Fusion
Study ID: NCT02576431
Conditions
Interventions
Study Description
Brief Summary: This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can therefore be used to treat cancer.
Detailed Description: The primary objective of this study is to investigate the efficacy of larotrectinib for the treatment of advanced solid tumors harboring a fusion of neurotrophic tyrosine receptor kinase (NTRK) of types 1-3 in children and adults. Secondary objectives comprise the efficacy and safety of larotrectinib in different NTRK-tumor types.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Stanford Cancer Center, Palo Alto, California, United States
UCLA-Santa Monica Medical Center, Santa Monica, California, United States
Memorial Hospital West, Pembroke, Florida, United States
University of Chicago, Chicago, Illinois, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
University of North Carolina Hospitals, Chapel Hill, North Carolina, United States
Wake Forest Baptist Health, Winston-Salem, North Carolina, United States
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Inova Schar Cancer Institute, Fairfax, Virginia, United States
University of Washington, Seattle, Washington, United States
West Virginia University, Morgantown, West Virginia, United States
Hospital Alemán, Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina
Fundacao Pio XII Hospital de Cancer de Barretos, Barretos/SP, Sao Paulo, Brazil
IBCC - Instituto Brasileiro de Controle do Cancer, São Paulo, Sao Paulo, Brazil
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Sichuan University West China Hospital, Chengdu, Sichuan, China
Beijing Cancer Hospital, Beijing, , China
Zhongshan Hospital, Fudan University, Shanghai, , China
Fakultni Nemocnice Olomouc, Olomouc, , Czechia
Finsen Centre, Copenhagen, , Denmark
Institut Bergonié - Unicancer Nouvelle Aquitaine, Bordeaux Cedex, , France
Centre Antoine Lacassagne, Nice Cedex 2, , France
Hopital Saint Antoine - Paris, Paris, , France
Hôpital de la Pitié-Salpétrière, Paris, , France
Institut de Cancérologie de l'Ouest - Saint Herblain, Saint-Herblain, , France
ICANS - Institut de Cancérologie de Strasbourg Europe, Strasbourg, , France
Charité Comprehensive Cancer Center (CCCC), Berlin, , Germany
All India Institute of Medical Sciences, Bhubaneswar, Delhi, India
Jawaharlal Institute Of Postgraduate Medical Education and R, Gorimedu, Pondicherry, India
St Vincents University Hospital, Dublin 4, , Ireland
Nagoya University Hospital, Nagoya, Aichi, Japan
National Cancer Center Hospital East, Kashiwa, Chiba, Japan
Hokkaido University Hospital, Sapporo, Hokkaido, Japan
The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo, Japan
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
IPO Porto, Porto, , Portugal
National Cancer Center Singapore, Singapore, , Singapore
Institut Català d'Oncologia Hospitalet, Hospitalet de Llobregat, Barcelona, Spain
Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona, , Spain
Hospital General Universitario Gregorio Maranon | Oncologia, Madrid, , Spain
Fundacion Jimenez Diaz (Clinica de la Concepcion), Madrid, , Spain
Centro Integral Oncológico Clara Campal, Madrid, , Spain
Karolinska Universitetssjukhuset i Solna, Stockholm, , Sweden
Tri-Service General Hospital, Taipei City, , Taiwan
Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara, , Turkey
Trakya Univ. Tip Fak., Edirne, , Turkey
Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi, Istanbul, , Turkey
TC Saglik Bakanligi Goztepe ProfDr Suleyman Yalcin Sehir Has, Istanbul, , Turkey
Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma, Izmir, , Turkey
Contact Details
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