Spots Global Cancer Trial Database for Dose Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 In Patients With Advanced Solid Tumors With Liver Involvement
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Trial Identification
Brief Title: Dose Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 In Patients With Advanced Solid Tumors With Liver Involvement
Official Title: A Multi-Center, Open Label, Phase 1 Dose-Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 in Patients With Advanced Solid Tumors With Liver Involvement
Study ID: NCT00882180
Conditions
Interventions
Study Description
Brief Summary: The purpose of the study is to determine the safety, tolerability, pharmacokinetics, and pharmacodynamics of intravenous ALN-VSP02, an RNAi therapeutic, in patients with advanced solid tumors with liver involvement.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
TGen Clinical Research Service at Scottsdale Healthcare, Scottsdale, Arizona, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Karmanos Cancer Center, Detroit, Michigan, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Hospital Virgen del Rocio, Seville, Andalucia, Spain
Hospital Universitario Vall d'Hebron, Barcelona, Catalonia, Spain
Hospital Clinico Universitario de Valencia, Valencia, , Spain
Contact Details
Name: Akshay Vaishnaw, MD PhD
Affiliation: Alnylam Pharmaceuticals
Role: STUDY_DIRECTOR
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