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Brief Title: A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Official Title: A Phase 1, Open-Label, Multicenter Study of INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Study ID: NCT06179160
Brief Summary: This study is conducted to determine the safety and tolerability of INCB161734 as a single agent or in combination with other anticancer therapies.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic Hospital, Phoenix, Arizona, United States
UCLA Healthcare Hematology-Oncology, Santa Monica, California, United States
Sarah Cannon Research Institue At Healthone, Denver, Colorado, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Weill Cornell Medicine, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Md Anderson Cancer Center, Houston, Texas, United States
Chris Obrien Lifehouse, Camperdown, New South Wales, Australia
St Vincent'S Hospital Sydney, Darlinghurst, New South Wales, Australia
The Alfred Hospital, Melbourne, Victoria, Australia
Peter Maccallum Cancer Centre, North Melbourne, Victoria, Australia
Linear Clinical Research, Nedlands, Western Australia, Australia
Cliniques Universitaires Ucl Saint-Luc, Brussels, , Belgium
Princess Margaret Cancer Center, Toronto, Ontario, Canada
Universitaire Du Cancer de Toulouse Institut Claudius Regaud Iuct-Oncopole, Toulouse, , France
Institut Gustave Roussy, Villejuif Cedex, , France
Irccs Istituto Clinico Humanitas, Rozzano, , Italy
Hospital General Universitario Vall D Hebron, Barcelona, , Spain
Name: Incyte Medical Monitor
Affiliation: Incyte Corporation
Role: STUDY_DIRECTOR