Spots Global Cancer Trial Database for A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
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Trial Identification
Brief Title: A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)
Official Title: Phase Ia, First in Human Open Label Dose Escalation Trial Evaluating Intravenous BI 1703880 in Combination With Intravenous Ezabenlimab for Treatment of Advanced Solid Tumours
Study ID: NCT05471856
Conditions
Study Description
Brief Summary: This study is open to adults with different types of advanced cancer. People can take part if previous treatment was not successful, or no treatment exists. The purpose of this study is to find the highest dose of a medicine called BI 1703880 that people with advanced cancer can tolerate when taken together with ezabenlimab. BI 1703880 and ezabenlimab are medicines that may help the immune system fight cancer. In this study, BI 1703880 is given to people for the first time. Participants get BI 1703880 and ezabenlimab as infusions into a vein. During the first 6 weeks, they get BI 1703880 once a week. Later, they get BI 1703880 every 3 weeks. After the first 3 weeks, they get ezabenlimab in addition every 3 weeks. Participants can get BI 1703880 for up to 1 year and ezabenlimab for up to 2 years as long as they benefit from treatment and can tolerate it. During this time, they visit the study site regularly. At these visits, the doctors check participants' health and take note of any unwanted effects.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Valkyrie Clinical Trials, Los Angeles, California, United States
Yale University School of Medicine, New Haven, Connecticut, United States
John Theurer Cancer Center, Hackensack, New Jersey, United States
National Cancer Center Hospital East, Chiba, Kashiwa, , Japan
Japanese Foundation for Cancer Research, Tokyo, Koto-ku, , Japan
Hospital Vall d'Hebron, Barcelona, , Spain
CIO Clara Campal, Madrid, , Spain
Hospital Clínico de Valencia, Valencia, , Spain
The Royal Marsden Hospital, Chelsea, London, , United Kingdom
Churchill Hospital, Oxford, , United Kingdom
The Royal Marsden Hospital, Sutton, Sutton, , United Kingdom
Contact Details
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