Spots Global Cancer Trial Database for Pilot Study of NKG2D-Ligand Targeted CAR-NK Cells in Patients With Metastatic Solid Tumours
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Trial Identification
Brief Title: Pilot Study of NKG2D-Ligand Targeted CAR-NK Cells in Patients With Metastatic Solid Tumours
Official Title: Pilot Study of NKG2D-Ligand Targeted CAR-NK Cells in Patients With Metastatic Solid Tumours
Study ID: NCT03415100
Conditions
Interventions
Study Description
Brief Summary: This is a single-centre, single arm, open-label pilot study to evaluate the safety and feasibility of CAR-NK cell treatment in subjects with metastatic solid tumours. Autologous or allogeneic NK cells are transfected by mRNA electroporation to prepare investigational CAR-NK cells with transiently enhanced specificity and activity against NKG2D-ligand expressing cancer cells.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Contact Details
Name: Xuehu Xu, MD
Affiliation: The Third Affiliated Hospital of Guangzhou Medical University
Role: PRINCIPAL_INVESTIGATOR
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