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Spots Global Cancer Trial Database for Window of Opportunity Study of Preoperative Immunotherapy With Atezolizumab in Local SCCHN

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Trial Identification

Brief Title: Window of Opportunity Study of Preoperative Immunotherapy With Atezolizumab in Local SCCHN

Official Title: Window of Opportunity Study of Preoperative Immunotherapy With Atezolizumab (Tecentriq®) in Local Head and Neck Squamous Cell Carcinoma (the PIONEER Trial)

Study ID: NCT04939480

Interventions

Atezolizumab

Study Description

Brief Summary: Targeting the PD-L1 pathway with atezolizumab has demonstrated objective responses across a broad range of malignancies including head and neck squamous cell carcinoma (SCCHN). MO39839 is a window of opportunity study investigating the feasibility, safety and postoperative complication rates of preoperative short time immunotherapy with atezolizumab in patients with local SCCHN. In the scope of MO39839 a comprehensive translational research program will be conducted to assess the potential effect of atezolizumab on dynamics in tumor immunity, and to identify and validate potential predictive and prognostic biomarkers.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University Hospital Essen, Essen, , Germany

Contact Details

Name: Stefan Kasper-Virchow, Prof. Dr.

Affiliation: University Hospital, Essen

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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