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Brief Title: Broxuridine Plus Surgery in Treating Patients With Stage I or Stage II Prostate Cancer
Official Title: Cell Kinetic Study of Bromodeoxyuridine (BrdU) in Prostate Cancer
Study ID: NCT00003832
Brief Summary: Phase II trial to study the effectiveness of broxuridine in treating patients who are undergoing surgery for stage I or stage II prostate cancer. Broxuridine may help doctors determine the rate of growth of prostate tumors and help them plan effective treatment
Detailed Description: OBJECTIVES: I. Measure the potential doubling times of multifocal adenocarcinomas of the prostate using broxuridine. II. Determine whether the doubling times of multifocal carcinomas occurring within a single prostate are consistent with a model in which low-volume carcinomas have slow doubling times and high-volume carcinomas have fast doubling times. OUTLINE: Patients receive broxuridine IV over 30 minutes on day -1. Approximately 12-96 hours later, patients undergo surgery to remove the prostate. Tumor tissue is examined by immunostaining for the presence of broxuridine to determine doubling times of the tumor.
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
University of Colorado, Denver, Colorado, United States
Name: Leonard Glode
Affiliation: University of Colorado, Denver
Role: PRINCIPAL_INVESTIGATOR