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Spots Global Cancer Trial Database for High-Intensity Interval Training for Stage I-III Breast Cancer Patients

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Trial Identification

Brief Title: High-Intensity Interval Training for Stage I-III Breast Cancer Patients

Official Title: High-Intensity Interval Training (HIT) for Breast Cancer Patients During Trastuzumab Use

Study ID: NCT02454777

Study Description

Brief Summary: This randomized pilot clinical trial studies the feasibility of high-intensity interval training in improving cardiovascular fitness in patients with stage I-III breast cancer undergoing chemotherapy with trastuzumab. Trastuzumab helps patients live longer, but may cause side effects to the heart. Aerobic exercise may help the heart function better, which may help protect it against side effects from trastuzumab. Exercise may also help reduce fatigue and prevent cancer from coming back. High-intensity interval training involves short bursts of higher intensity efforts with longer periods of recovery. This may also allow patients who cannot exercise for a long period of time to still be physically active. This trial studies whether patients can tolerate high-intensity interval training, and how well it works in improving fitness in patients with breast cancer receiving trastuzumab.

Detailed Description: PRIMARY OBJECTIVES: I. To assess the feasibility (completion of \> 80% exercise sessions) of utilizing high-intensity interval training (HIT). II. To determine the effects of HIT on aerobic exercise adaptation when compared to delayed group. III. To examine the effects of HIT on left ventricular function when compared to delayed group. IV. To determine the effects of HIT on endothelial function, arterial stiffness, and vascular atherosclerosis when compared to delayed group. OUTLINE: Participants are randomized to 1 of 2 groups. ARM I: HIT (High-intensity Interval Training) group - Participants undergo HIT over 30 minutes, thrice weekly for 8 weeks. ARM II: DEL (Delayed/usual care) group - Participants maintain their current sedentary activity level (\< 60 minutes of total exercise per week) for 8 weeks. Participants document their weekly activity in an exercise log. Following completion of all study visits, participants are given the option to complete the HIT exercise program as in Arm I. After completion of study, patients are followed up at weeks 9 and 17.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Contact Details

Name: Christina Dieli-Conwright

Affiliation: University of Southern California

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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