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Spots Global Cancer Trial Database for Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery

Official Title: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

Study ID: NCT01872975

Study Description

Brief Summary: This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether comprehensive radiation therapy is more effective than standard radiation therapy in treating patients with breast cancer

Detailed Description: PRIMARY OBJECTIVES: To evaluate whether the addition of chest wall + regional nodal radiation therapy (XRT) after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for invasive breast cancer recurrence-free interval (IBC-RFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy. SECONDARY OBJECTIVES: I. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly prolong overall survival (OS) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy. II. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rates of events for local-regional recurrence-free interval (LRRFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy. III. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for distant recurrence-free interval (DRFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy. IV. To compare the rates of disease-free survival (DFS)-ductal carcinoma in situ (DCIS) by treatment arm. V. To compare the rates of second primary cancer (SPC) by treatment arm. VI. To compare the effect of adding XRT on the cosmetic outcomes in mastectomy patients who have had reconstruction. VII. To compare the effect of adding XRT on quality of life including arm problems, lymphedema, pain, and fatigue. VIII. To evaluate the toxicity associated with each of the radiation therapy regimens. IX. To determine whether computed tomography (CT)-based conformal methods (intensity-modulated radiation therapy \[IMRT\] and 3-dimensional conformal radiation therapy \[3DCRT\]) for chestwall + regional nodal XRT post mastectomy and regional nodal XRT with breast XRT following breast conserving surgery are feasible in a multi-institutional setting and whether dose-volume analyses can be established to assess treatment adequacy and to develop normal tissue complication probabilities (NTCP) for the likelihood of toxicity. X. To compare the effect of XRT in patients receiving mastectomy and in patients receiving lumpectomy. XI. To examine the role of proliferation measures as a prognosticator for patients with residual disease after neoadjuvant chemotherapy. XII. To develop predictors of the degree of reduction in local regional recurrence (LRR). OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM 1: Patients are assigned to 1 of 2 treatment groups. GROUP 1A: Lumpectomy patients undergo whole breast radiation therapy using IMRT or 3DCRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks. GROUP 1B: Mastectomy patients do not undergo radiation therapy. ARM 2: Patients are assigned to 1 of 2 treatment groups. GROUP 2A: Lumpectomy patients undergo regional nodal radiation therapy with whole breast radiation therapy using IMRT or 3DCRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks. GROUP 2B: Mastectomy patients undergo regional nodal radiation therapy and chestwall XRT using IMRT or 3DCRT once daily 5 days a week for 5 weeks. All patients also receive systemic therapy as planned (hormonal therapy for patients with hormone-receptor positive breast cancer and trastuzumab or other anti-human epidermal growth factor receptor 2 \[HER2\] therapy for patients with breast cancer that is HER2-positive). After completion of study treatment, patients are followed up at 6, 12, 18, and 24 months and then yearly for 8 years.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States

Providence Alaska Medical Center, Anchorage, Alaska, United States

Arizona Breast Cancer Specialists-Gilbert, Gilbert, Arizona, United States

Arizona Center for Cancer Care-Peoria, Peoria, Arizona, United States

Arizona Breast Cancer Specialists-Phoenix, Phoenix, Arizona, United States

Arizona Breast Cancer Specialists-Scottsdale, Scottsdale, Arizona, United States

Arizona Center for Cancer Care-Surprise, Surprise, Arizona, United States

Arizona Oncology Associates-West Orange Grove, Tucson, Arizona, United States

The University of Arizona Medical Center-University Campus, Tucson, Arizona, United States

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States

Mills - Peninsula Hospitals, Burlingame, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States

Eden Hospital Medical Center, Castro Valley, California, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

Epic Care-Dublin, Dublin, California, United States

Epic Care Partners in Cancer Care, Emeryville, California, United States

California Cancer Center - North Fresno, Fresno, California, United States

UC San Diego Moores Cancer Center, La Jolla, California, United States

City of Hope Antelope Valley, Lancaster, California, United States

Loma Linda University Medical Center, Loma Linda, California, United States

Los Angeles County-USC Medical Center, Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Cedars-Sinai Medical Center, Los Angeles, California, United States

Hoag Memorial Hospital, Newport Beach, California, United States

Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States

Kaiser Permanente Oakland-Broadway, Oakland, California, United States

Saint Joseph Hospital - Orange, Orange, California, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States

Desert Regional Medical Center, Palm Springs, California, United States

Huntington Memorial Hospital, Pasadena, California, United States

Pomona Valley Hospital Medical Center, Pomona, California, United States

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California, United States

Rohnert Park Cancer Center, Rohnert Park, California, United States

Kaiser Permanente-Roseville, Roseville, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, United States

Sutter Roseville Medical Center, Roseville, California, United States

The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California, United States

Sutter General Hospital, Sacramento, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

Saint Helena Hospital, Saint Helena, California, United States

Naval Medical Center -San Diego, San Diego, California, United States

Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States

City of Hope South Pasadena, South Pasadena, California, United States

Kaiser Permanente Cancer Treatment Center, South San Francisco, California, United States

Kaiser Permanente-South San Francisco, South San Francisco, California, United States

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, United States

Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States

Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado, United States

University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora, Colorado, United States

Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Memorial Hospital Colorado Springs, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

The Shaw Regional Cancer Center, Edwards, Colorado, United States

Poudre Valley Hospital, Fort Collins, Colorado, United States

Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado, United States

Saint Mary Corwin Medical Center, Pueblo, Colorado, United States

Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado, United States

SCL Health Lutheran Medical Center, Wheat Ridge, Colorado, United States

Hartford Hospital, Hartford, Connecticut, United States

Middlesex Hospital, Middletown, Connecticut, United States

The Hospital of Central Connecticut, New Britain, Connecticut, United States

MedStar Georgetown University Hospital, Washington, District of Columbia, United States

MedStar Washington Hospital Center, Washington, District of Columbia, United States

Sibley Memorial Hospital, Washington, District of Columbia, United States

Florida Hospital Cancer Institute Altamonte, Altamonte Springs, Florida, United States

John Fitzgerald Kennedy Medical Center, Atlantis, Florida, United States

Morton Plant Hospital, Clearwater, Florida, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida, United States

University of Florida, Gainesville, Florida, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida, United States

Jackson Memorial Hospital-Holtz Children's Hospital, Miami, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, United States

South Miami Hospital, Miami, Florida, United States

Baptist Hospital of Miami, Miami, Florida, United States

Florida Hospital Orlando, Orlando, Florida, United States

UF Cancer Center at Orlando Health, Orlando, Florida, United States

21st Century Oncology-Palatka, Palatka, Florida, United States

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida, United States

Moffitt Cancer Center, Tampa, Florida, United States

Grady Health System, Atlanta, Georgia, United States

Emory University Hospital Midtown, Atlanta, Georgia, United States

Piedmont Hospital, Atlanta, Georgia, United States

Emory University/Winship Cancer Institute, Atlanta, Georgia, United States

Saint Joseph's Hospital of Atlanta, Atlanta, Georgia, United States

Tanner Medical Center/Carrollton, Carrollton, Georgia, United States

Dekalb Medical Center, Decatur, Georgia, United States

Memorial University Medical Center, Savannah, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, United States

The Cancer Center of Hawaii-Leeward, 'Ewa Beach, Hawaii, United States

Queen's Medical Center, Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Kootenai Cancer Center, Post Falls, Idaho, United States

Mount Sinai Hospital Medical Center, Chicago, Illinois, United States

Northwestern University, Chicago, Illinois, United States

John H Stroger Jr Hospital of Cook County, Chicago, Illinois, United States

University of Illinois, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

AMITA Health Alexian Brothers Medical Center, Elk Grove Village, Illinois, United States

Elmhurst Memorial Hospital, Elmhurst, Illinois, United States

NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois, United States

NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois, United States

Advocate South Suburban Hospital, Hazel Crest, Illinois, United States

NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois, United States

Presence Saint Mary's Hospital, Kankakee, Illinois, United States

Condell Memorial Hospital, Libertyville, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

Edward Hospital/Cancer Center, Naperville, Illinois, United States

UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois, United States

Advocate Christ Medical Center, Oak Lawn, Illinois, United States

Advocate Lutheran General Hospital, Park Ridge, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois, United States

SwedishAmerican Regional Cancer Center/ACT, Rockford, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, United States

Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson, Indiana, United States

Parkview Hospital Randallia, Fort Wayne, Indiana, United States

Goshen Center for Cancer Care, Goshen, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

IU Health Methodist Hospital, Indianapolis, Indiana, United States

Community Cancer Center East, Indianapolis, Indiana, United States

Community Cancer Center South, Indianapolis, Indiana, United States

Franciscan Health Indianapolis, Indianapolis, Indiana, United States

Community Cancer Center North, Indianapolis, Indiana, United States

Saint Vincent Hospital and Health Care Center, Indianapolis, Indiana, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Mercy Cancer Center-West Lakes, Clive, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas, United States

Via Christi Regional Medical Center, Wichita, Kansas, United States

Wesley Medical Center, Wichita, Kansas, United States

Wichita NCI Community Oncology Research Program, Wichita, Kansas, United States

Saint Elizabeth Medical Center South, Edgewood, Kentucky, United States

Saint Elizabeth Fort Thomas, Fort Thomas, Kentucky, United States

Norton Hospital Pavilion and Medical Campus, Louisville, Kentucky, United States

The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States

Baptist Health Louisville, Louisville, Kentucky, United States

Norton Suburban Hospital and Medical Campus, Louisville, Kentucky, United States

Owensboro Health Mitchell Memorial Cancer Center, Owensboro, Kentucky, United States

Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States

Woman's Hospital, Baton Rouge, Louisiana, United States

Mary Bird Cancer Center/Saint Tammany Parish, Covington, Louisiana, United States

Mary Bird Perkins Cancer Center/Terrebonne General Medical Center, Houma, Louisiana, United States

Ochsner Medical Center Kenner, Kenner, Louisiana, United States

Ochsner Medical Center Jefferson, New Orleans, Louisiana, United States

Eastern Maine Medical Center, Bangor, Maine, United States

Maine Medical Center- Scarborough Campus, Scarborough, Maine, United States

Anne Arundel Medical Center, Annapolis, Maryland, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Greater Baltimore Medical Center, Baltimore, Maryland, United States

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore, Maryland, United States

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States

Upper Chesapeake Medical Center, Bel Air, Maryland, United States

Central Maryland Radiation Oncology in Howard County, Columbia, Maryland, United States

Tate Cancer Center, Glen Burnie, Maryland, United States

Boston Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Saint Anne's Hospital, Fall River, Massachusetts, United States

Lowell General Hospital, Lowell, Massachusetts, United States

Baystate Medical Center, Springfield, Massachusetts, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Henry Ford Cancer Institute¿Downriver, Brownstown, Michigan, United States

21st Century Oncology-Clarkston, Clarkston, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan, United States

Beaumont Hospital-Dearborn, Dearborn, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Saint John Hospital and Medical Center, Detroit, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

McLaren Cancer Institute-Flint, Flint, Michigan, United States

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States

Sparrow Hospital, Lansing, Michigan, United States

McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan, United States

McLaren Cancer Institute-Macomb, Mount Clemens, Michigan, United States

McLaren Cancer Institute-Central Michigan, Mount Pleasant, Michigan, United States

Mercy Health Mercy Campus, Muskegon, Michigan, United States

Assarian Cancer Center, Novi, Michigan, United States

McLaren Cancer Institute-Owosso, Owosso, Michigan, United States

McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan, United States

Saint Joseph Mercy Oakland, Pontiac, Michigan, United States

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan, United States

Providence Hospital-Southfield Cancer Center, Southfield, Michigan, United States

21st Century Oncology-Troy, Troy, Michigan, United States

William Beaumont Hospital - Troy, Troy, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan, United States

Metro Health Hospital, Wyoming, Michigan, United States

Mayo Clinic Health System in Albert Lea, Albert Lea, Minnesota, United States

Fairview Ridges Hospital, Burnsville, Minnesota, United States

Unity Hospital, Fridley, Minnesota, United States

Mayo Clinic Health Systems-Mankato, Mankato, Minnesota, United States

Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States

Mayo Clinic Radiation Therapy-Northfield, Northfield, Minnesota, United States

Mayo Clinic, Rochester, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States

Regions Hospital, Saint Paul, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

Ridgeview Medical Center, Waconia, Minnesota, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

Baptist Memorial Hospital-Desoto, Southhaven, Mississippi, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Saint Luke's Hospital, Chesterfield, Missouri, United States

University of Missouri - Ellis Fischel, Columbia, Missouri, United States

Barnes-Jewish West County Hospital, Creve Coeur, Missouri, United States

Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States

North Kansas City Hospital, Kansas City, Missouri, United States

The University of Kansas Cancer Center-South, Kansas City, Missouri, United States

Research Medical Center, Kansas City, Missouri, United States

The University of Kansas Cancer Center-North, Kansas City, Missouri, United States

The University of Kansas Cancer Center-Lee's Summit, Lee's Summit, Missouri, United States

Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Saint Anthony's Medical Center, Saint Louis, Missouri, United States

Siteman Cancer Center-South County, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Siteman Cancer Center - Saint Peters, Saint Peters, Missouri, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

CHI Health Saint Francis, Grand Island, Nebraska, United States

Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States

Alegent Health Lakeside Hospital, Omaha, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

Concord Hospital, Concord, New Hampshire, United States

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Elliot Hospital, Manchester, New Hampshire, United States

Memorial Sloan Kettering Cancer Center at Basking Ridge, Basking Ridge, New Jersey, United States

Ocean Medical Center, Brick, New Jersey, United States

Cooper Hospital University Medical Center, Camden, New Jersey, United States

Englewood Hospital and Medical Center, Englewood, New Jersey, United States

Saint Barnabas Medical Center, Livingston, New Jersey, United States

Virtua Memorial, Mount Holly, New Jersey, United States

Jersey Shore Medical Center, Neptune, New Jersey, United States

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States

The Valley Hospital-Luckow Pavilion, Paramus, New Jersey, United States

Capital Health Medical Center-Hopewell, Pennington, New Jersey, United States

Riverview Medical Center/Booker Cancer Center, Red Bank, New Jersey, United States

Valley Hospital, Ridgewood, New Jersey, United States

Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey, United States

Sparta Cancer Treatment Center, Sparta, New Jersey, United States

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey, United States

Virtua Voorhees, Voorhees, New Jersey, United States

Valley Health System-Hematology/Oncology, Westwood, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Lovelace Radiation Oncology, Albuquerque, New Mexico, United States

New Mexico Oncology Hematology Consultants, Albuquerque, New Mexico, United States

Memorial Medical Center - Las Cruces, Las Cruces, New Mexico, United States

Christus Saint Vincent Regional Cancer Center, Santa Fe, New Mexico, United States

Montefiore Medical Center - Moses Campus, Bronx, New York, United States

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York, United States

Maimonides Medical Center, Brooklyn, New York, United States

Putnam Hospital Center, Carmel, New York, United States

Memorial Sloan Kettering Commack, Commack, New York, United States

Mary Imogene Bassett Hospital, Cooperstown, New York, United States

Vassar Brothers Fishkill Radiation Oncology Center, Fishkill, New York, United States

Memorial Sloan Kettering Westchester, Harrison, New York, United States

Ulster Radiation Oncology Center, Kingston, New York, United States

Columbia University/Herbert Irving Cancer Center, New York, New York, United States

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Vassar Brothers Medical Center, Poughkeepsie, New York, United States

Rochester General Hospital, Rochester, New York, United States

Pluta Cancer Center, Rochester, New York, United States

Memorial Sloan Kettering Rockville Centre, Rockville Centre, New York, United States

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow, New York, United States

State University of New York Upstate Medical University, Syracuse, New York, United States

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, United States

Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States

Carolinas Medical Center/Levine Cancer Institute-Pineville, Charlotte, North Carolina, United States

Carolinas Medical Center/Levine Cancer Institute-University, Charlotte, North Carolina, United States

Carolinas HealthCare System NorthEast, Concord, North Carolina, United States

Duke University Medical Center, Durham, North Carolina, United States

CaroMont Regional Medical Center, Gastonia, North Carolina, United States

Cone Health Cancer Center, Greensboro, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

Matthews Radiation Oncology Center, Matthews, North Carolina, United States

Carolinas HealthCare System Union, Monroe, North Carolina, United States

South Atlantic Radiation Oncology, Supply, North Carolina, United States

Coastal Carolina Radiation Oncology, Wilmington, North Carolina, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Summa Akron City Hospital/Cooper Cancer Center, Akron, Ohio, United States

Akron General Medical Center, Akron, Ohio, United States

Summa Barberton Hospital, Barberton, Ohio, United States

UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio, United States

Aultman Health Foundation, Canton, Ohio, United States

Geaugra Hospital, Chardon, Ohio, United States

University of Cincinnati/Barrett Cancer Center, Cincinnati, Ohio, United States

Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, United States

Bethesda North Hospital, Cincinnati, Ohio, United States

Case Western Reserve University, Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

The Mark H Zangmeister Center, Columbus, Ohio, United States

Mount Carmel Health Center West, Columbus, Ohio, United States

Delaware Radiation Oncology, Delaware, Ohio, United States

Cleveland Clinic Cancer Center Independence, Independence, Ohio, United States

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States

Summa Health Center at Lake Medina, Medina, Ohio, United States

Lake University Ireland Cancer Center, Mentor, Ohio, United States

Southwest General Health Center Ireland Cancer Center, Middleburg Heights, Ohio, United States

University Hospitals Parma Medical Center, Parma, Ohio, United States

North Coast Cancer Care, Sandusky, Ohio, United States

Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio, United States

University Pointe, West Chester, Ohio, United States

UHHS-Westlake Medical Center, Westlake, Ohio, United States

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio, United States

Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma, United States

Willamette Valley Cancer Center, Eugene, Oregon, United States

Compass Oncology Rose Quarter, Portland, Oregon, United States

Kaiser Permanente Northwest, Portland, Oregon, United States

Mid-Columbia Medical Center/Celilo Cancer Center, The Dalles, Oregon, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania, United States

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania, United States

Northeast Radiation Oncology Center, Dunmore, Pennsylvania, United States

Ephrata Cancer Center, Ephrata, Pennsylvania, United States

The Regional Cancer Center, Erie, Pennsylvania, United States

Fox Chase Cancer Center Buckingham, Furlong, Pennsylvania, United States

Adams Cancer Center, Gettysburg, Pennsylvania, United States

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania, United States

PinnacleHealth Cancer Center-Community Campus, Harrisburg, Pennsylvania, United States

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

Lancaster General Hospital, Lancaster, Pennsylvania, United States

Holy Redeemer Hospital and Medical Center, Meadowbrook, Pennsylvania, United States

Intercommunity Cancer Center, Monroeville, Pennsylvania, United States

UPMC-Coraopolis/Heritage Valley Radiation Oncology, Moon, Pennsylvania, United States

Allegheny Valley Hospital, Natrona Heights, Pennsylvania, United States

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States

Pennsylvania Hospital, Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Temple University Hospital, Philadelphia, Pennsylvania, United States

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Saint Margaret, Pittsburgh, Pennsylvania, United States

UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania, United States

Reading Hospital, West Reading, Pennsylvania, United States

Wexford Health and Wellness Pavilion, Wexford, Pennsylvania, United States

WellSpan Health-York Hospital, York, Pennsylvania, United States

Rhode Island Hospital, Providence, Rhode Island, United States

Radiation Oncology Associates Incorporated, Providence, Rhode Island, United States

Women and Infants Hospital, Providence, Rhode Island, United States

Kent County Hospital, Warwick, Rhode Island, United States

Roper Hospital, Charleston, South Carolina, United States

Bon Secours Saint Francis Hospital, Charleston, South Carolina, United States

Medical University of South Carolina, Charleston, South Carolina, United States

Georgetown Hospital System, Georgetown, South Carolina, United States

Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Faris, Greenville, South Carolina, United States

Saint Francis Cancer Center, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Eastside, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Greer, Greer, South Carolina, United States

Gibbs Cancer Center-Pelham, Greer, South Carolina, United States

The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island, South Carolina, United States

Greenville Health System Cancer Institute-Seneca, Seneca, South Carolina, United States

Spartanburg Medical Center, Spartanburg, South Carolina, United States

Greenville Health System Cancer Institute-Spartanburg, Spartanburg, South Carolina, United States

Lexington Medical Center, West Columbia, South Carolina, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

The West Clinic - Wolf River, Germantown, Tennessee, United States

Thompson Cancer Survival Center, Knoxville, Tennessee, United States

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee, United States

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, United States

Texas Cancer Center, Abilene, Texas, United States

The Don and Sybil Harrington Cancer Center, Amarillo, Texas, United States

Texas Oncology-Arlington South, Arlington, Texas, United States

Texas Oncology-Austin Midtown, Austin, Texas, United States

Texas Oncology - Central Austin Cancer Center, Austin, Texas, United States

Texas Oncology - South Austin Cancer Center, Austin, Texas, United States

Texas Oncology Bedford, Bedford, Texas, United States

Parkland Memorial Hospital, Dallas, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States

Texas Oncology-Flower Mound, Flower Mound, Texas, United States

The Klabzuba Cancer Center, Fort Worth, Texas, United States

Memorial Hermann Memorial City Medical Center, Houston, Texas, United States

M D Anderson Cancer Center, Houston, Texas, United States

The Methodist Hospital System, Houston, Texas, United States

MD Anderson Regional Care Center-Katy, Houston, Texas, United States

Doctor's Hospital of Laredo, Laredo, Texas, United States

Covenant Medical Center-Lakeside, Lubbock, Texas, United States

University Medical Center, Lubbock, Texas, United States

Texas Tech University Health Sciences Center-Lubbock, Lubbock, Texas, United States

MD Anderson Regional Care Center-Bay Area, Nassau Bay, Texas, United States

Texas Oncology-Plano West, Plano, Texas, United States

Scott and White Healthcare Round Rock, Round Rock, Texas, United States

Texas Oncology - Round Rock Cancer Center, Round Rock, Texas, United States

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Texas Cancer Center-Sherman, Sherman, Texas, United States

MD Anderson Regional Care Center-Sugar Land, Sugar Land, Texas, United States

Texas Oncology Cancer Center Sugar Land, Sugar Land, Texas, United States

Scott and White Memorial Hospital, Temple, Texas, United States

MD Anderson Regional Care Center-The Woodlands, The Woodlands, Texas, United States

Deke Slayton Cancer Center, Webster, Texas, United States

Intermountain Medical Center, Murray, Utah, United States

Utah Valley Regional Medical Center, Provo, Utah, United States

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States

South Jordan Health Center, South Jordan, Utah, United States

Norris Cotton Cancer Center-North, Saint Johnsbury, Vermont, United States

Inova Alexandria Hospital, Alexandria, Virginia, United States

University of Virginia Cancer Center, Charlottesville, Virginia, United States

Inova Fairfax Hospital, Falls Church, Virginia, United States

Augusta Health Cancer Center, Fishersville, Virginia, United States

Mary Washington Hospital, Fredericksburg, Virginia, United States

Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton, Virginia, United States

Sentara Norfolk General Hospital, Norfolk, Virginia, United States

Naval Medical Center - Portsmouth, Portsmouth, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

Oncology and Hematology Associates of Southwest Virginia, Roanoke, Virginia, United States

Sentara Virginia Beach General Hospital, Virginia Beach, Virginia, United States

MultiCare Auburn Medical Center, Auburn, Washington, United States

Overlake Hospital Medical Center, Bellevue, Washington, United States

Harrison Medical Center, Bremerton, Washington, United States

Virginia Mason Federal Way Medical Center, Federal Way, Washington, United States

Tacoma/Valley Radiation Oncology Centers-Gig Harbor, Gig Harbor, Washington, United States

MultiCare Gig Harbor Medical Park, Gig Harbor, Washington, United States

Tri-Cities Cancer Center, Kennewick, Washington, United States

Skagit Valley Hospital Regional Cancer Care Center, Mount Vernon, Washington, United States

MultiCare Good Samaritan Hospital, Puyallup, Washington, United States

Tacoma/Valley Radiation Oncology Centers-Puyallup, Puyallup, Washington, United States

Virginia Mason Medical Center, Seattle, Washington, United States

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Seattle Cancer Care Alliance, Seattle, Washington, United States

University of Washington Medical Center, Seattle, Washington, United States

Cancer Care Northwest - Spokane South, Spokane, Washington, United States

Spokane Valley Cancer Center-Mayfair, Spokane, Washington, United States

MultiCare Tacoma General Hospital, Tacoma, Washington, United States

Northwest Medical Specialties PLLC, Tacoma, Washington, United States

Saint Joseph Medical Center, Tacoma, Washington, United States

Tacoma/Valley Radiation Oncology Centers-Saint Joe's, Tacoma, Washington, United States

Compass Oncology Vancouver, Vancouver, Washington, United States

West Virginia University Healthcare, Morgantown, West Virginia, United States

Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States

Fox Valley Surgical Associates Limited, Appleton, Wisconsin, United States

Radiology Associates of Appleton/ThedaCare Regional Medical Center, Appleton, Wisconsin, United States

ThedaCare Regional Cancer Center, Appleton, Wisconsin, United States

Sacred Heart Hospital, Eau Claire, Wisconsin, United States

Aurora Cancer Care-Grafton, Grafton, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States

Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin, United States

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, United States

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Marshfield Clinic, Marshfield, Wisconsin, United States

Saint Joseph's Hospital, Marshfield, Wisconsin, United States

Community Memorial Hospital, Menomonee Falls, Wisconsin, United States

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States

Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States

Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, United States

Surgical Associates of Neenah SC, Neenah, Wisconsin, United States

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States

Wheaton Franciscan Cancer Care - All Saints, Racine, Wisconsin, United States

Marshfield Clinic-Rice Lake Center, Rice Lake, Wisconsin, United States

Saint Michael's Hospital, Stevens Point, Wisconsin, United States

Marshfield Clinic Stevens Point Center, Stevens Point, Wisconsin, United States

Aurora Medical Center in Summit, Summit, Wisconsin, United States

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin, United States

ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin, United States

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States

Aurora West Allis Medical Center, West Allis, Wisconsin, United States

The Alyce and Elmore Kraemer Cancer Care Center, West Bend, Wisconsin, United States

Diagnostic and Treatment Center, Weston, Wisconsin, United States

Tom Baker Cancer Centre, Calgary, Alberta, Canada

Cross Cancer Institute, Edmonton, Alberta, Canada

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John, New Brunswick, Canada

University Health Network-Princess Margaret Hospital, Toronto, Ontario, Canada

CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada

McGill University Department of Oncology, Montreal, Quebec, Canada

Jewish General Hospital, Montreal, Quebec, Canada

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec, Canada

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada

Saint Lukes Hospital, Dublin, Co Dublin, Ireland

University College Hospital Galway, Galway, Co Galway, Ireland

Chaim Sheba Medical Center, Tel Hashomer, , Israel

Tohoku University School of Medicine, Sendai, Aoba-ku, Japan

Hokkaido University Hospital, Sapporo, Hokkaido, Japan

Hyogo Cancer Center, Akashi-city, Hyogo, Japan

Iwate Medical University School of Medicine, Morioka, Iwate, Japan

Gunma University Hospital, Gunma, Maebashi, Japan

Niigata University Medical and Dental Hospital, Niigata City, Niigata, Japan

Shikoku Cancer Center, Matsuyama, , Japan

Saitama Medical University International Medical Center, Saitama, , Japan

Yonsei University Health System-Severance Hospital, Seoul, , Korea, Republic of

San Juan City Hospital, San Juan, , Puerto Rico

Contact Details

Name: Norman Wolmark, MD

Affiliation: NSABP Foundation Inc

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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